5-氨基-2,4-二氯吡啶 | 7321-93-9

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-氨基-2,4-二氯吡啶
• 中文别名: 2,4-二氯-5-氨基吡啶；4,6-二氯吡啶-3-胺
• 英文名称: 4,6-dichloropyridin-3-amine
• 英文别名: 5-amino-2,4-dichloropyridine；5-Amino-2,4-dichlor-pyridin
• CAS: 7321-93-9
• 化学式: C₅H₄Cl₂N₂
• mdl: MFCD00234054
• 分子量: 163.006
• InChiKey: FBGVTWONYOCYGA-UHFFFAOYSA-N

物化性质

• 熔点：
  80-81 °C(Solv: ligroine (8032-32-4))
• 沸点：
  290.8±35.0 °C(Predicted)
• 密度：
  1.497±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  6.1
• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302+H312+H332,H315,H319,H335
• 储存条件：
  存储条件：2-8°C，避光，惰性气体环境中保存。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 5-Amino-2,4-dichloropyridine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 5-Amino-2,4-dichloropyridine
CAS number: 7321-93-9

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C5H4Cl2N2
Molecular weight: 163.0

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  5-氨基-2,4-二氯吡啶 在 盐酸 、 铜 、 sodium nitrite 作用下， 生成 2,4,5-三氯吡啶
  参考文献：
  名称：

  den Hertog et al., Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 673,690

  摘要：

  DOI：
• 作为产物：
  描述：

  4,6-二羟基烟酸乙酯 在 氢氧化钾 、 sodium hydroxide 、 五氯化磷 、 溴 、 三氯氧磷 作用下， 生成 5-氨基-2,4-二氯吡啶
  参考文献：
  名称：

  den Hertog et al., Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 673,690

  摘要：

  DOI：

文献信息

• New pyridodihydropyrazinones, process for their manufacture and use thereof as medicaments
  申请人：Hoffmann Matthias

  公开号：US20060009457A1

  公开（公告）日：2006-01-12

  Disclosed are pyridodihydropyrazinone compounds, processes for preparing them and their use as pharmaceutical compositions. The compounds according to the invention correspond to general formula (I), while the groups L, R 1 , R 2 , R 3 , R 4 and R 5 may have the meanings given in the claims and specification.

  揭示了吡啶二氢吡嗪酮化合物，其制备方法以及它们作为药物组合物的用途。根据本发明的化合物符合一般式(I)，而其中的基团L、R1、R2、R3、R4和R5可能具有权利要求和说明书中给定的含义。
• 作为BET蛋白和极体样激酶的双重抑制剂的取代的二氢吡啶并[3,4-b]吡嗪酮
  申请人：拜耳制药股份公司

  公开号：CN105555786A

  公开（公告）日：2016-05-04

  本发明涉及作为BET蛋白（尤其是BRD4蛋白）和极体样激酶（尤其是Plk-1蛋白）的双重抑制剂的通式(I)的取代的二氢吡啶并[3,4-b]吡嗪酮，其中A、X、R 1 、R 2 、R 3 、R 4 、R 5 、R 6 、R 7 和n各自如在说明书中所定义，涉及用于制备根据本发明的化合物的中间体，涉及包含根据本发明的化合物的药物组合物，和涉及它们在过度增生性疾病的情况下、特别是在肿瘤疾病的情况下的预防和治疗用途。此外，本发明涉及根据本发明的二氢吡啶并[3,4-b]吡嗪酮在病毒感染中、在神经变性疾病中、在炎症疾病中、在动脉粥样硬化性疾病中和在雄性生育控制中的用途。
• Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics
  申请人：Stingray Therapeutics, Inc.

  公开号：US20200039979A1

  公开（公告）日：2020-02-06

  Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

  取代的-3H-咪唑[4,5-c]吡啶和1H-吡咯[2,3-c]吡啶系列新型胞外核苷酸焦磷酸酶/磷酸二酯酶-1 (ENPP1)及相关化合物，其作为ENPP1的抑制剂是有用的；制造这些化合物的方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与ENPP1功能障碍相关的疾病的方法。
• [EN] HETEROCYCLIC COMPOUNDS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES
  申请人：KYORIN SEIYAKU KK

  公开号：WO2015129927A1

  公开（公告）日：2015-09-03

  Provided herein are compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of ERK5, a BET family protein or both. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of a ERK5 -mediated disease, a BET protein-mediated disease or both.

  本文提供了公式I的化合物和含有这些化合物的组合物。这些化合物和组合物在抑制ERK5的作用、BET家族蛋白的作用或两者的方法中是有用的。在某些实施方式中，这些化合物和组合物在预防、改善或治疗ERK5介导的疾病、BET蛋白介导的疾病或两者的方法中是有用的。
• [EN] FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE<br/>[FR] COMPOSÉS BICYCLIQUES FUSIONNÉS UTILISÉS COMME INHIBITEURS DE LA PI3 KINASE
  申请人：MERCK SERONO SA

  公开号：WO2010100144A1

  公开（公告）日：2010-09-10

  The invention relates to compounds of formula (I) for the regulation of phosphoinositides 3-kinases activity and related diseases.

  该发明涉及用于调节磷脂酰肌醇3-激酶活性及相关疾病的化合物（I）的公式。