5-氨基-2-(2-氯苯基)-4-羟基呋喃-3-酮 | 13011-88-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氨基-2-(2-氯苯基)-4-羟基呋喃-3-酮
• 英文名称: 5-Amino-2-(2-chlorophenyl)-4-hydroxyfuran-3-one
• CAS: 13011-88-6
• 化学式: C₁₀H₈ClNO₃
• 分子量: 225.63
• InChiKey: JDQMPPSFXHZKCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-氨基-2-(2-氯苯基)-4-羟基呋喃-3-酮 、 三乙胺 、 苄磺酰氯 、 氯化铵 在 氩 、 乙醚 、 水 、 Brine 、 Sodium sulfate-III 、 甲醇 作用下， 以 四氢呋喃 为溶剂， 反应 16.5h， 生成 2-amino-5-(2-chlorophenyl)-4-oxo-4,5-dihydrofuran-3-yl phenylmethanesulfonate
  参考文献：
  名称：

  Inhibitors of Beta-Hydroxylase for Treatment of Cancer

  摘要：

  本发明涉及调节β-羟化酶（例如天冬氨酸（天冬氨酰）β-羟化酶（ASPH））活性的化合物，包括新的2-芳基-5-氨基-3（2H）-呋喃酮和2-杂环芳基-5-氨基-3（2H）-呋喃酮化合物，其制药组合物，合成方法，以及使用这些化合物在无细胞样品、细胞基因测定和受试者中调节ASPH活性的方法。本发明的其他方面涉及使用在此处披露的化合物来改善或治疗细胞增殖障碍。

  公开号：

  US20150210677A1

文献信息

• Inhibitors of beta-hydroxylase for treatment of cancer
  申请人：MIDWESTERN UNIVERSITY

  公开号：US10106532B2

  公开（公告）日：2018-10-23

  The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.

  本发明涉及调节（如抑制）β-水解酶（如ASPH）活性的化合物，包括新型2-芳基-5-氨基-3(2H)-呋喃酮和2-杂芳基-5-氨基-3(2H)-呋喃酮化合物、其药物组合物、其合成方法以及使用这些化合物调节无细胞样本、基于细胞的测定和受试者体内ASPH活性的方法。本发明的其他方面涉及使用本文公开的化合物来改善或治疗细胞增殖障碍。
• Inhibitors of β-hydroxylase for treatment of cancer
  申请人：Midwestern University

  公开号：US10351555B2

  公开（公告）日：2019-07-16

  The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.

  本发明涉及调节（如抑制）β-水解酶（如ASPH）活性的化合物，包括新型2-芳基-5-氨基-3(2H)-呋喃酮和2-杂芳基-5-氨基-3(2H)-呋喃酮化合物、其药物组合物、其合成方法以及使用这些化合物调节无细胞样本、基于细胞的测定和受试者体内ASPH活性的方法。本发明的其他方面涉及使用本文公开的化合物来改善或治疗细胞增殖障碍。
• INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER
  申请人：Rhode Island Hospital

  公开号：EP2897607A2

  公开（公告）日：2015-07-29
• INHIBITORS OF BETA-HYDROXYLASE FOR TREATMENT OF CANCER
  申请人：Rhode Island Hospital

  公开号：US20180237427A1

  公开（公告）日：2018-08-23

  The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
• Inhibitors of Beta-Hydoxylase for Treatment of Cancer
  申请人：Midwestern University

  公开号：US20220251076A1

  公开（公告）日：2022-08-11

  The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.