Facile one-pot preparation of allylic alcohols with a fluorine-containing alkyl group at the γ-position
摘要:
A useful one-pot preparation method of allylic alcohols with fluorinated alkyl groups at the gamma position was developed from the corresponding enoates by way of the DIBAL-mediated half reduction, followed by nucleophilic attack of Grignard reagents to aldehydes equilibrating with aluminium acetals. (C) 2013 Elsevier B.V. All rights reserved.
Direct hydroperfluoroalkylation of ethyl propiolate with perfluoroalkyl iodides and bromides by a Co/Zn bimetal redox system
作者:Chang-Ming Hu、Yao-Ling Qiu
DOI:10.1016/s0022-1139(00)81261-0
日期:1991.11
The addition of perfluoroalkyl halides RfX (1) (X=I, Br) to ethyl propiolate (2) has been performed smoothly with zinc powder and a catalytic amount of bromo(pyridine)cobaloxime(III) (3) in ethanol. The product (4) was a mixture of Z- and E-isomers, with the former predominating.
用锌粉和在乙醇中催化量的溴(吡啶)钴氧肟(III)(3)平稳地将全氟烷基卤化物R f X(1)(X = I,Br)添加到丙酸乙酯(2)中。产物(4)是Z-和E-异构体的混合物,其中前者占主导地位。