(Z)-O-methylbenzohydroximoyl cyanide | 130691-11-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-O-methylbenzohydroximoyl cyanide
• 英文别名: (Z)-N-methoxybenzenecarboximidoyl cyanide
• CAS: 130691-11-1
• 化学式: C₉H₈N₂O
• 分子量: 160.175
• InChiKey: CFCKRUVZXMAVKE-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  45.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-O-methylbenzohydroximoyl cyanide 在 sodium methylate 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 生成 (E)-O-methylbenzohydroximoyl cyanide
  参考文献：
  名称：

  （Z）-和（E）-O-甲基苯并氧肟基氰化物中甲醇离子取代的立体化学和动力学

  摘要：

  研究了甲醇离子取代反应（Z）-和（E）-甲基苯并氧代肟基氰基[PhC（CN）NOCH 3 ]的立体化学和动力学。（Z）-羟肟基氰化物与甲醇钠在DMSO-甲醇（9：1）溶液中于44·8°C反应，得到（Z）-O-甲基苯并氢肟酸甲酯[PhC（OCH 3）NOCH 3 ]的混合物和α-酮苯基乙酰胺PhC（CONH 2）NOCH 3的O-甲基肟。（E）-羟肟基氰化物经历甲氧根离子催化异构化为E-异构体比经历亲核取代的速度更快。这些观察结果是根据加成消除机制来解释的，其中限速步骤是消除核沉子（A N + D N＃）。

  DOI：

  10.1002/poc.610070704

文献信息

• [EN] COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE<br/>[FR] COMPOSÉS UTILES COMME INHIBITEURS DE LA KINASE ATR
  申请人：VERTEX PHARMA

  公开号：WO2011143426A1

  公开（公告）日：2011-11-17

  The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I wherein the variables are as defined herein.

  本发明涉及可用于作为ATR蛋白激酶抑制剂的吡嗪和吡啶化合物。本发明还涉及包含本发明化合物的药用可接受组合物；使用本发明化合物治疗各种疾病、障碍和状况的方法；制备本发明化合物的方法；制备本发明化合物的中间体；以及使用化合物进行体外应用的方法，例如研究生物和病理现象中的激酶；研究由这类激酶介导的细胞内信号转导途径；以及比较评估新的激酶抑制剂。本发明的化合物具有式I，其中变量如所定义。
• A process for producing (E)-alkoxyimino or hydroxyiminoacetamide compounds and intermediates therefor
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA

  公开号：EP0596692A2

  公开（公告）日：1994-05-11

  The present invention relates to a process for producing (E)-alkoxyiminoacetamide compounds useful as agricultural fungicides and a process for producing (E)-hydroxyiminoacetamide compounds useful as intermediates for producing them. The present invention also relates to an industrial process for producing (E)-methoxyiminoacetamide compounds useful as agricultural fungicides. This process is advantageous in terms of the cost, safety and the like.

  本发明涉及一种生产用作农用杀菌剂的(E)-烷氧基亚氨基乙酰胺化合物的工艺和一种生产用作生产(E)-羟基亚氨基乙酰胺化合物中间体的(E)-羟基亚氨基乙酰胺化合物的工艺。本发明还涉及一种生产用作农用杀菌剂的(E)-甲氧基亚氨基乙酰胺化合物的工业工艺。该工艺在成本、安全性等方面具有优势。
• Benzyl compounds and process for producing same
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA

  公开号：EP0741125A1

  公开（公告）日：1996-11-06

  A process for producing benzyl compounds of the formula: wherein A2 is alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkenyl, optionally substituted phenyl or an optionally substituted heterocyclic group, and X is halogen, which comprises reacting a compound of the formula:         A2-OH   (II) with a compound of the formula (III): Also disclosed are certain novel benzyl compounds of the above formula and also derived from the above benzyl compounds. The compounds are useful intermediates in the preparation of (E)-alkoxyiminoacetamide compounds useful as agricultural fungicides.

  一种生产式苄基化合物的工艺： 其中A2是烷基、烯基、炔基、烷氧基、环烷基、环烯基、任选取代的苯基或任选取代的杂环基团，X是卤素，该工艺包括使式如下的化合物反应 A2-OH (II) 与式 (III) 的化合物反应： 还公开了某些上述式的新型苄基化合物以及由上述苄基化合物衍生的新型苄基化合物。 这些化合物是制备(E)-烷氧基亚氨基乙酰胺化合物的有用中间体，可用作农用杀菌剂。
• Lithographic printing plate precursor and lithographic printing method
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP1754614A1

  公开（公告）日：2007-02-21

  The invention is directed to a lithographic printing plate precursor comprising a support and an image-recording layer, wherein the image-recording layer comprises (1) an infrared absorber and (2) a photochromic compound. The invention is also directed to a method of plate making and a lithographic printing method, each method using the lithographic printing plate precursor.

  本发明涉及一种平版印刷板前体，包括一个支撑物和一个图像记录层，其中图像记录层包括(1)红外线吸收剂和(2)光致变色化合物。本发明还涉及一种制版方法和一种平版印刷方法，每种方法都使用平版印刷板前体。
• INKJET PRINTER AND IMAGE-FORMING METHOD
  申请人：Konica Minolta Medical & Graphic, Inc.

  公开号：EP2030792A1

  公开（公告）日：2009-03-04

  Disclosed is an ink-jet printer which uses an actinic ray-curable ink-jet ink containing a cationic-polymerizable compound and is capable of performing stable image recording with inhibiting formation of precipitates within the printer and an image forming method by use thereof. The ink-jet printer ejecting an ink comprising a cationic-polymerizable compound onto a recording medium, characterized in that the ink-jet printer comprises ink-contact members which constitute an ink tank retaining the ink and an ink supply passage of from the ink tank to a recording head ejecting the ink and the ink-contact members are each comprised of a material which does substantially not undergo electron transfer with the ink.

  本发明公开了一种喷墨打印机，该打印机使用含有阳离子可聚合化合物的放 射线固化喷墨墨水，能够在抑制打印机内沉淀物形成的同时进行稳定的图像记录， 并公开了使用该打印机的图像形成方法。将含有阳离子可聚合化合物的墨水喷射到记录介质上的喷墨打印机，其特征在于，喷墨打印机包括墨水接触部件，这些部件构成一个墨水槽，用于保存墨水，以及一个从墨水槽到喷射墨水的记录头的供墨通道，墨水接触部件均由基本上不与墨水发生电子转移的材料构成。