5-氨基-2-羟基苯甲酰胺 | 59393-77-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氨基-2-羟基苯甲酰胺
• 英文名称: 5-Amino-2-hydroxy-benzamid
• 英文别名: 5-Amino-salicylamid；5-amino-2-hydroxy-benzoic acid amide；5-Amino-salicylsaeureamid；5-Amino-2-hydroxy-benzoesaeure-amid；4-amino-2-carbamoylphenol；5-amino-2-hydroxybenzamide
• CAS: 59393-77-0
• 化学式: C₇H₈N₂O₂
• 分子量: 152.153
• InChiKey: XLKBBIACESHASR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-氨基-2-羟基苯甲酰胺 、 氯乙酰氯 在 sodium acetate 、 溶剂黄146 作用下， 生成 5-(2-chloro-acetylamino)-2-hydroxy-benzoic acid amide
  参考文献：
  名称：

  Jacobs; Heidelberger, Journal of the American Chemical Society, 1917, vol. 39, p. 2437

  摘要：

  DOI：
• 作为产物：
  描述：

  3-硝基苯甲酰胺 在 硫酸 作用下， 生成 5-氨基-2-羟基苯甲酰胺
  参考文献：
  名称：

  Jacobs; Heidelberger, Journal of the American Chemical Society, 1917, vol. 39, p. 2437

  摘要：

  DOI：

文献信息

• Phenylboronic acid complexing reagents derived from aminosalicylic acid
  申请人：Prolinx, Inc.

  公开号：US05594151A1

  公开（公告）日：1997-01-14

  The present invention relates to a novel class of phenylboronic acid complexing reagents useful for the preparation of bioconjugates, and the method of making and using such reagents. In the present invention, in the place of prior art Avidin-Biotin and Digoxigenin-anti-Digoxigenin systems, phenylboronic acid complexing reagents are utilized in conjunction with phenylboronic acid reagents (many of which are known in the prior art) to facilitate chemical conjugation without the use of intermediary biological macromolecules. Reagents suitable for the modification of a bioactive species for the purpose of incorporating a phenylboronic acid complexing moiety for subsequent conjugation to a different bioactive species having pendant phenylboronic acid moleties are of General Formula I or General Formula II. ##STR1## wherein group X is selected from either H, OH, NH.sub.2, NHCH.sub.3, NHOH and NHOCH.sub.3, wherein group Y is selected from either O, S and NH, and wherein group Z comprises a spacer which either separates the boronic acid complexing moiety from group R, as in General Formula I, or seperates two boronic acid complexing moieties, as in General Formula II. Group R is a reactive electrophilic or nucleophilic moiety suitable for reaction of the phenylboronic acid complexing reagent with a bioactive species.

  本发明涉及一种新型苯硼酸络合试剂类，用于制备生物共轭物，并且涉及制备和使用此类试剂的方法。在本发明中，苯硼酸络合试剂与苯硼酸试剂（其中许多已知于现有技术）一起使用，以取代以往的亲和素-生物素和地高辛-抗地高辛系统，从而在不使用中间生物大分子的情况下促进化学共轭。适用于修饰生物活性物种以将苯硼酸络合基团并入以后与具有挂链苯硼酸基团的不同生物活性物种共轭的试剂的一般公式I或一般公式II如下：##STR1## 其中，基团X从H、OH、NH.sub.2、NHCH.sub.3、NHOH和NHOCH.sub.3中选择，基团Y从O、S和NH中选择，基团Z包括将硼酸络合基团与基团R分离的间隔，如一般式I中所示，或将两个硼酸络合基团分离的间隔，如一般式II中所示。基团R是适合将苯硼酸络合试剂与生物活性物种反应的反应性亲电或亲核基团。
• Phenylboronic acid complexing reagents derived from aminolalicylic acid
  申请人：Prolinx, Inc.

  公开号：US05668257A1

  公开（公告）日：1997-09-16

  The present invention relates to a novel class of phenylboronic acid complexing reagents useful for the preparation of bioconjugates, and the method of making and using such reagents. In the present invention, in the place of prior art Avidin-Biotin and Digoxigenin-anti-Digoxigenin systems, phenylboronic acid complexing reagents are utilized in conjunction with phenylboronic acid reagents (many of which are known in the prior art) to facilitate chemical conjugation without the use of intermediary biological macromolecules. Reagents suitable for the modification of a bioactive species for the purpose of incorporating a phenylboronic acid complexing moiety for subsequent conjugation to a different bioactive species having pendant phenylboronic acid moieties are of General Formula I or General Formula II. ##STR1## wherein group X is selected from either H, OH, NH.sub.2, NHCH.sub.3, NHOH and NHOCH.sub.3, wherein group Y is selected from either O, S and NH, and wherein group Z comprises a spacer which either separates the boronic acid complexing moiety from group R, as in General Formula I, or separates two boronic acid complexing moieties, as in General Formula II. Group R is a reactive electrophilic or nucleophilic moiety suitable for reaction of the phenylboronic acid complexing reagent with a bioactive species.

  本发明涉及一种新型苯硼酸络合试剂类，可用于制备生物共轭物，并且涉及制备和使用这种试剂的方法。在本发明中，使用苯硼酸络合试剂代替现有技术中的Avidin-Biotin和Digoxigenin-anti-Digoxigenin系统，与苯硼酸试剂（其中许多已知于现有技术中）一起使用，以促进化学共轭，而不使用中间生物大分子。适用于修饰生物活性物种的试剂，以便将苯硼酸络合基团并入具有悬垂苯硼酸基团的不同生物活性物种进行后续共轭，其为通用式I或通用式II。其中，基团X从H、OH、NH.sub.2、NHCH.sub.3、NHOH和NHOCH.sub.3中选择，基团Y从O、S和NH中选择，基团Z包括一个间隔物，该间隔物将硼酸络合基团与基团R分开，如通用式I中，或将两个硼酸络合基团分开，如通用式II中。基团R是适用于试剂与生物活性物种反应的反应性亲电性或亲核性基团。
• Dye composition for keratinous fiber
  申请人：Kao Corporation

  公开号：EP0345728A2

  公开（公告）日：1989-12-13

  A hair dyeing composition comprising a special developer and a coupling agent is disclosed. The developer is a 4-aminophenol derivative substituted at the 2-position which is represented by the following formula (I), in which X represents a group -NHCOR¹ (R¹ is a linear or branched alkyl group having 1-5 carbon atoms), a group -COOR² [R² is a hydrogen atom, a linear or branched alkyl group having 1-5 carbon atoms, a monohydroxy alkyl group having 1-5 carbon atoms, a polyhydroxy alkyl group having 1-5 carbon atoms, or a group -(CH₂)nNR³R⁴ (R³ and R⁴ individually represent a hydrogen atom or a linear or branched alkyl group having 1-5 carbon atoms, and n denotes an integer of 1-5)], a group -CONHR², a nitrile group, a group -SO₃R², or a group -SO₂NR22 (R² has the same meaning as defined above and the two R²s may be the same or different), or a salt thereof. The dye composition provides a high degree of saturation and vividness of colors as well as good fastness.

  本发明公开了一种由特殊显影剂和偶联剂组成的染发组合物。该显影剂是一种在 2 位被取代的 4-氨基苯酚衍生物，由下式（I）表示、 其中 X 代表基团-NHCOR¹（R¹ 是具有 1-5 个碳原子的直链或支链烷基）、基团-COOR²[R² 是氢原子、具有 1-5 个碳原子的直链或支链烷基、具有 1-5 个碳原子的单羟基烷基、具有 1-5 个碳原子的多羟基烷基、或基团-(CH₂)nNR³R⁴（R³ 和 R⁴ 分别代表氢原子或具有 1-5 个碳原子的直链或支链烷基，n 表示 1-5 的整数）]、基团-CONHR²、腈基、基团-SO₃R² 或基团-SO₂NR22（R² 的含义与上述定义相同，两个 R² 可以相同或不同），或其盐。该染料组合物具有较高的色彩饱和度和鲜艳度以及良好的牢度。
• PHENYLBORONIC ACID COMPLEXES
  申请人：PROLINX, INC.

  公开号：EP0741734A1

  公开（公告）日：1996-11-13
• HIGH OIL CONTENT PLANTS
  申请人：Bayer BioScience N.V.

  公开号：EP2440034A1

  公开（公告）日：2012-04-18