N-Methacryloyl-3-methoxy-anilin | 15271-60-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Methacryloyl-3-methoxy-anilin
• 英文别名: methacrylic acid m-anisidide；Methacrylsaeure-m-anisidid；N-(3-methoxyphenyl)-2-methylprop-2-enamide
• CAS: 15271-60-0
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: OCJRPRBAYHJUPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-Methacryloyl-3-methoxy-anilin 在 双(二氧化硫)-1,4-二氮杂双环[2.2.2]辛烷加合物 、 sodium hydride 作用下， 以 四氢呋喃 、 1,2-二氯乙烷 、 mineral oil 为溶剂， 反应 28.33h， 生成 3-(((fluoromethyl)sulfonyl)methyl)-4-methoxy-1,3-dimethylindolin-2-one
  参考文献：
  名称：

  Visible-Light-Induced, Catalyst-Free Monofluoromethyl Sulfonylation of Alkenes with Iodine(III) Reagent and DABSO

  摘要：

  DOI：

  10.1021/acs.orglett.3c02766
• 作为产物：
  描述：

  间氨基苯甲醚 、 甲基丙烯酰氯 生成 N-Methacryloyl-3-methoxy-anilin
  参考文献：
  名称：

  Sokolowa; Owsjannikowa, Zhurnal Obshchei Khimii, 1953, vol. 28, p. 779,780,781;engl.Ausg.S.757

  摘要：

  DOI：

文献信息

• Nontraditional Application of the Photo-Fenton Process: A Novel Strategy for Molecular Construction Using Formamide and Flow Chemistry
  作者：Marialy N. Sanabria、Milene M. Hornink、Valquíria G. Correia、Leandro H. Andrade

  DOI：10.1021/acs.oprd.0c00057

  日期：2020.10.16

  Instead of destroying organic compounds, for the first time the photo-Fenton reaction was employed to construct them. Oxindole and spiro-oxindole scaffolds, which are frequently found in natural products, were selected as molecular targets. The development of a photochemical flow reactor employing the photo-Fenton reaction in formamide resulted in an excellent synthetic methodology for oxindoles. Non-anhydrous

  取代破坏有机化合物，第一次是采用光芬顿反应来构建它们。选择天然产物中常见的羟吲哚和螺-羟吲哚支架作为分子靶标。使用在甲酰胺中的光芬顿反应的光化学流反应器的开发导致了对吲哚的极好的合成方法。需要无水条件，并使用容易获得的化学品和温和条件。同样，使用官能化的吲哚作为关键中间体有效地开发了新的螺环化合物的新型合成方法。
• EGFR proteolysis targeting chimeric molecules and associated methods of use
  申请人：Arvinas Operations, Inc.

  公开号：US10994015B2

  公开（公告）日：2021-05-04

  The present disclosure relates to bifunctional compounds, which find utility as modulators of receptor tyrosine kinase (RTK) proteins. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand which binds to an E3 ubiquitin ligase and on the other end a moiety which binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effectuate ubiquitination, and therefore, degradation (and inhibition) of the target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作受体酪氨酸激酶（RTK）蛋白的调节剂。特别是，本公开涉及双功能化合物，其一端含有与 E3 泛素连接酶结合的配体，另一端含有与靶蛋白结合的分子，从而使靶蛋白靠近泛素连接酶以实现泛素化，进而降解（和抑制）靶蛋白。本公开内容展示了与靶蛋白降解/抑制相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防因目标蛋白聚集或积聚而导致的疾病或失调。
• Synthesis of 2-Pyridones and Iminoesters via Rh(III)-Catalyzed Oxidative Coupling between Acrylamides and Alkynes
  作者：Yan Su、Miao Zhao、Keli Han、Guoyong Song、Xingwei Li

  DOI：10.1021/ol102306c

  日期：2010.12.3

  Catalytic oxidative coupling between acrylamides and alkynes was achieved using 0.5 mol % loading of [RhCp*Cl-2](2) with Cu(OAc)(2) as an oxidant. 2-Pyridones, iminoesters, and substituted indoles could be obtained as a result of the electronic and steric effects of the substituents in the acrylamides.
• Muehlstaedt, Manfred; Uhlmann, Heike, Zeitschrift fur Chemie, 1987, vol. 27, # 1, p. 34 - 35
  作者：Muehlstaedt, Manfred、Uhlmann, Heike

  DOI：——

  日期：——
• MUHLSTADT M.; UHLMANN H., Z. CHEM., 27,(1987) N 1, 34-35
  作者：MUHLSTADT M.、 UHLMANN H.

  DOI：——

  日期：——