5-(3-chlorophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | 1326305-17-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 5-(3-chlorophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
• 英文别名: 5-(3-chlorophenyl)-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
• CAS: 1326305-17-2
• 化学式: C₁₅H₁₅ClN₄O
• 分子量: 302.763
• InChiKey: IMYXLJFBPMDWKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  59.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-甲基-3-丙基-1H-吡唑-5-甲酸 在 氯化亚砜 、 硫酸 、 硝酸 、 铁粉 、 氯化铵 作用下， 以 乙醇 、 水 为溶剂， 反应 20.5h， 生成 5-(3-chlorophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
  参考文献：
  名称：

  [EN] PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF
  [FR] PYRAZOLOPYRIMIDINONES POUR LE TRAITEMENT DE L'IMPUISSANCE ET PROCÉDÉ DE PRÉPARATION CORRESPONDANT

  摘要：

  本发明涉及作为PDE5抑制剂的吡唑嘧啶酮化合物，具有更好的IC50值、良好的体内有效性和PK特性，以及其制备方法。本发明涵盖基于吡唑嘧啶酮的化合物，这些化合物已经被设计、合成和筛选用于PDE5抑制活性，其PDE5抑制潜力在本发明中提供。这些设计的化合物在筛选PDE5抑制活性时表现出纳摩尔级的效力，并且在体内表现出更好的有效性。这些化合物可以用于治疗男性勃起功能障碍或阳痿的治疗。

  公开号：

  WO2015114647A1

文献信息

• Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US10017511B2

  公开（公告）日：2018-07-10

  The present invention relates to Pyrazolopyrimidinone compounds as PDE5 inhibitors with better IC50 value, good in vivo efficacy and PK profile and a process for the preparation thereof. The present invention covers the pyrazolo pyrimidinone based compounds that have been designed, synthesized and screened for PDE5 inhibitory activity and its PDE5 inhibitory potential is provided in this invention. These designer compounds have shown nanomolar potency when screened for PDE5 inhibitory activity and also shown better in vivo efficacy. These compounds can be used in the treatment of male erectile dysfunction or in the treatment of impotence.

  本发明涉及吡唑嘧啶酮类化合物作为PDE5抑制剂，具有较好的IC50值、良好的体内疗效和PK谱及其制备工艺。本发明涵盖了经过设计、合成和筛选的具有 PDE5 抑制活性的吡唑并嘧啶酮类化合物，本发明提供了其 PDE5 抑制潜力。这些设计化合物在进行 PDE5 抑制活性筛选时显示出纳摩尔效力，并显示出较好的体内疗效。这些化合物可用于治疗男性勃起功能障碍或阳痿。
• Synthesis of 5-substituted-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors
  作者：G. Lakshma Reddy、Santosh Kumar Guru、M. Srinivas、Anup Singh Pathania、Priya Mahajan、Amit Nargotra、Shashi Bhushan、Ram A. Vishwakarma、Sanghapal D. Sawant

  DOI：10.1016/j.ejmech.2014.04.051

  日期：2014.6

  A microwave assisted strategy for synthesis of series of 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones has been developed and their biological evaluation as anticancer agents is described. The synthetic protocol involves simple procedure by oxidative coupling of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide with different aldehydes in presence of K2S2O8 offering 5-substituted-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one compounds in excellent yields. The in vitro anticancer activity screening against human cancer cell lines HeLa, CAKI-I, PC-3, MiaPaca-2, A549 gave good results. The in detailed mechanistic correlation studies of compound 3m revealed that the compound shows anticancer activity through apoptosis mechanism and also inhibits mTOR with nonomolar potency. The design was based on docking with mTOR protein. The concentration dependent cell cycle analysis, western blotting experiment and nuclear cell morphology studies have been described.
• InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents
  作者：Naveen Mulakayala、Bhaskar Kandagatla、Ismail、Rajesh Kumar Rapolu、Pallavi Rao、Chaitanya Mulakayala、Chitta Suresh Kumar、Javed Iqbal、Srinivas Oruganti

  DOI：10.1016/j.bmcl.2012.06.003

  日期：2012.8

  A convenient and practical methodology for the synthesis of 2-aryl quinazolin-4(3H)-ones by the condensation of o-aminobenzamides with aromatic aldehydes under mild conditions using catalytic InCl3 with good yields and high selectivities. This method has been extended for the synthesis of 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones which have potential applications in medicinal chemistry. Many of these compounds were evaluated for their anti-proliferative properties in vitro against four cancer cell lines and several compounds were found to be active. Further in vitro studies indicated that inhibition of sirtuins could be the possible mechanism of action of these molecules. (C) 2012 Elsevier Ltd. All rights reserved.
• PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Council of Scientific and Industrial Research

  公开号：EP3099689B1

  公开（公告）日：2022-01-26
• [EN] PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF<br/>[FR] PYRAZOLOPYRIMIDINONES POUR LE TRAITEMENT DE L'IMPUISSANCE ET PROCÉDÉ DE PRÉPARATION CORRESPONDANT
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2015114647A1

  公开（公告）日：2015-08-06

  The present invention relates to Pyrazolopyrimidinone compounds as PDE5 inhibitors with better IC50 value, good in vivo efficacy and PK profile and a process for the preparation thereof. The present invention covers the pyrazolo pyrimidinone based compounds that have been designed, synthesized and screened for PDE5 inhibitory activity and its PDE5 inhibitory potential is provided in this invention. These designer compounds have shown nanomolar potency when screened for PDE5 inhibitory activity and also shown better in vivo efficacy. These compounds can be used in the treatment of male erectile dysfunction or in the treatment of impotence.

  本发明涉及作为PDE5抑制剂的吡唑嘧啶酮化合物，具有更好的IC50值、良好的体内有效性和PK特性，以及其制备方法。本发明涵盖基于吡唑嘧啶酮的化合物，这些化合物已经被设计、合成和筛选用于PDE5抑制活性，其PDE5抑制潜力在本发明中提供。这些设计的化合物在筛选PDE5抑制活性时表现出纳摩尔级的效力，并且在体内表现出更好的有效性。这些化合物可以用于治疗男性勃起功能障碍或阳痿的治疗。