2,6-Octatrienoic acid | 5205-32-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,6-Octatrienoic acid
• 英文别名: (2E,4E,6Z)-octa-2,4,6-trienoic acid
• CAS: 5205-32-3
• 化学式: C₈H₁₀O₂
• 分子量: 138.16
• InChiKey: IAAPVNQZSBLWKH-ZQCKCTFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2916190090

文献信息

• DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
  申请人：Giuliani Giammaria

  公开号：US20110224298A1

  公开（公告）日：2011-09-15

  The present invention relates to a novel use of compounds having the general formula (I): CH 3 (—CH═CH) n —R  (I) where n=from 2 to 7, and R is chosen from among: CHO, CH 2 OH, CH 2 O—CO—R′, CO—OR′, CO—O (−) , where R′ is chosen from among H, the alkyl from C 1 to C 22 , each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.

  本发明涉及具有通式（I）的化合物的新用途： CH3（—CH═CH）n—R  (I) 其中n=2至7，R选择自：CHO，CH2OH，CH2O—CO—R′，CO—OR′，CO—O（−），其中R′选择自：H，C1至C22的烷基。每个通式（I）的化合物被用作活性原料，单独或混合使用，用于制备医药或化妆品组合物，通过细胞角蛋白cK-19介导的角蛋白的生产，提高人类表皮细胞修复活性。
• Compounds with a skin pigmenting activity and pharmaceutical or cosmetic compositions containing them
  申请人：Giuliani S.p.A.

  公开号：EP2407163A1

  公开（公告）日：2012-01-18

  The present invention relates to compounds having general formula (I):          CH3-(CH=CH)n-R     (I) where: n = 3, 5, 7; R is chosen from -CH2-O-CO-R', -CO-OR' or -CO-O(-), R' is chosen from H, C1-C22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.

  本发明涉及通式 (I) 的化合物： CH3-(CH=CH)n-R (I) 其中：n = 3、5、7；R 选自 -CH2-O-CO-R'、-CO-OR' 或 -CO-O(-)，R' 选自 H、C1-C22 烷基或烯基、芳基或芳烷基或糖； 及其药学上可接受的盐（如钠盐、钾盐和赖氨酸盐），用作药物或化妆品组合物中的活性成分，用于改善人体皮肤的色素沉着，治疗色素沉着疾病和/或改善皮肤的光保护能力及其晒黑的强度。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2857400A1

  公开（公告）日：2015-04-08

  The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种具有优异的 JAK 抑制作用的化合物，该化合物可用作预防或治疗自身免疫性疾病（类风湿性关节炎、银屑病、炎症性肠病、Sjogren 综合征、白塞氏病、多发性硬化症、系统性红斑狼疮等）、癌症（白血病、子宫白肌瘤、前列腺癌、多发性骨髓瘤、恶病质、骨髓纤维化等）的药物或其盐。 本发明涉及一种由式表示的化合物，其中各符号如说明书中所定义，或其盐。
• THE USE OF COMPOUNDS TO INHIBIT 5A-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
  申请人：Giuliani S.p.A.

  公开号：EP2373302A1

  公开（公告）日：2011-10-12
• THE USE OF COMPOUNDS TO INHIBIT 5alpha-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
  申请人：Giuliani S.p.A.

  公开号：EP2373302B1

  公开（公告）日：2017-09-13