A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis
作者:Martyn Inman、Christopher J. Moody
DOI:10.1039/c0cc04306k
日期:——
In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange, quenching with di-tert-butyl azodicarboxylate, followed by reaction with ketones under acidic conditions.
Two-Step Route to Indoles and Analogues from Haloarenes: A Variation on the Fischer Indole Synthesis
作者:Martyn Inman、Anna Carbone、Christopher J. Moody
DOI:10.1021/jo201866c
日期:2012.2.3
In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen–magnesium exchange and quenching with di-tert-butyl azodicarboxylate, followed by reaction with aldehydes or ketones under acidic conditions. The protocol, which is readily extended to the preparation of indole isosteres, 4- and 6-azaindoles and thienopyrroles