5-tert-butyl-3-(diphenylphosphino)-2-methoxybenzaldehyde | 163273-45-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-tert-butyl-3-(diphenylphosphino)-2-methoxybenzaldehyde
• 英文别名: 5-tert-butyl-3-diphenylphosphanyl-2-methoxybenzaldehyde
• CAS: 163273-45-8
• 化学式: C₂₄H₂₅O₂P
• 分子量: 376.435
• InChiKey: XQLVWQRIJRBZJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.56
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  5-tert-butyl-3-(diphenylphosphino)-2-methoxybenzaldehyde 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到5-tert-butyl-3-diphenylphosphino-salicyaldehyde
  参考文献：
  名称：

  Synthesis of acyclic dinucleating Schiff base-pyridine and schiff base-phosphine ligands

  摘要：

  5-tert-butyl-3-pyridyl-salicyaldehyde and 5-tert-butyl-3-diphenylphosphino-salicyaldehyde have been synthesized from 4-tert-butylphenol in good overall yields. Condensation of the salicyaldehydes with 2,3-diamino-2,3-dimethylbutane afforded the desired dinucleating Schiff base-pyridine and Schiff base-phosphine ligands respectively.

  DOI：

  10.1016/0040-4039(94)02372-i
• 作为产物：
  描述：

  2,6-二溴-4-叔丁基苯酚 在 sodium hydroxide 、 正丁基锂 、 四甲基乙二胺 作用下， 以 乙醚 为溶剂， 反应 6.0h， 生成 5-tert-butyl-3-(diphenylphosphino)-2-methoxybenzaldehyde
  参考文献：
  名称：

  Binucleating Ligands:  Synthesis of Acyclic Achiral and Chiral Schiff Base−Pyridine and Schiff Base−Phosphine Ligands

  摘要：

  5-tert-Butyl-3-(2'-pyridyl)salicyaldehyde and 5-tert-butyl-3-(diphenylphosphino)salicyaldehyde were synthesized from 4-tert-butylphenol in good overall yields. Condensation of the salicyaldehydes with 2,3-diamino-2,3-dimethylbutane afforded the desired dinucleating Schiff base-pyridine and Schiff base-phosphine ligands, respectively. 5-tert-Butyl-3-(2'-pyridyl) salicyaldehyde reacted with optically active 1,2-diaminocyclohexanes to give chiral dinucleating Schiff base-pyridine ligands.

  DOI：

  10.1021/jo961020f

文献信息

• Synthesis of acyclic dinucleating Schiff base-pyridine and schiff base-phosphine ligands
  作者：Fung Lam、Kin Shing Chan

  DOI：10.1016/0040-4039(94)02372-i

  日期：1995.2

  5-tert-butyl-3-pyridyl-salicyaldehyde and 5-tert-butyl-3-diphenylphosphino-salicyaldehyde have been synthesized from 4-tert-butylphenol in good overall yields. Condensation of the salicyaldehydes with 2,3-diamino-2,3-dimethylbutane afforded the desired dinucleating Schiff base-pyridine and Schiff base-phosphine ligands respectively.
• Binucleating Ligands:  Synthesis of Acyclic Achiral and Chiral Schiff Base−Pyridine and Schiff Base−Phosphine Ligands
  作者：Fung Lam、Jia Xi Xu、Kin Shing Chan

  DOI：10.1021/jo961020f

  日期：1996.1.1

  5-tert-Butyl-3-(2'-pyridyl)salicyaldehyde and 5-tert-butyl-3-(diphenylphosphino)salicyaldehyde were synthesized from 4-tert-butylphenol in good overall yields. Condensation of the salicyaldehydes with 2,3-diamino-2,3-dimethylbutane afforded the desired dinucleating Schiff base-pyridine and Schiff base-phosphine ligands, respectively. 5-tert-Butyl-3-(2'-pyridyl) salicyaldehyde reacted with optically active 1,2-diaminocyclohexanes to give chiral dinucleating Schiff base-pyridine ligands.