5-氨基-6-氟-正亮氨酸 | 116292-10-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 5-氨基-6-氟-正亮氨酸
• 英文名称: 5-Fluoromethylornithine
• 英文别名: 2,5-diamino-6-fluorohexanoic acid
• CAS: 116292-10-5
• 化学式: C₆H₁₃FN₂O₂
• mdl: MFCD20645639
• 分子量: 164.18
• InChiKey: PRNUWRQQLDXHRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] FLUORINE SUBSTITUTED CECLOHEXENE ANALOGOUES OF GAMMA-AMINOBUTYRIC ACID (GABA)<br/>[FR] ANALOGUES DE CYCLOHEXÈNE SUBSTITUÉS PAR DU FLUOR DE L'ACIDE GAMMA-AMINOBUTYRIQUE (GABA)
  申请人：UNIV NORTHWESTERN

  公开号：WO2021081523A1

  公开（公告）日：2021-04-29

  Disclosed are amino, fluoro-sub stituted cyclohexene carboxylic acid compounds. The disclosed compounds and compositions thereof may be utilized in methods for modulating ornithine aminotransferase (OAT) activity, including methods for treating diseases or disorders associated with OAT activity or expression such as cell proliferative diseases and disorders.

  本文披露了氨基，氟代取代的环己烯羧酸化合物。所披露的化合物及其组合物可用于调节鸟氨酸氨基转移酶（OAT）活性的方法，包括用于治疗与OAT活性或表达相关的疾病或障碍的方法，如细胞增殖性疾病和障碍。
• Preparation of aminoacetonitrile derivatives
  申请人：MERRELL TORAUDE ET COMPAGNIE

  公开号：EP0046710A1

  公开（公告）日：1982-03-03

  2-Fluorinated methyl aminoacetonitriles are prepared by treating a corresponding fluorinated methyl ketimine magnesium halide with hydrogen cyanide or with an alkali metal cyanide or ammonium cyanide and a proton source.

  用氰化氢或碱金属氰化物或氰化铵和质子源处理相应的氟化甲基酮亚胺卤化镁，可制备 2-氟化甲基氨基乙腈。
• Use of inhibitors of ornithine aminotransferase for the manufacture of a medicament for the treatment of Alzheimer's disease
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0609630A1

  公开（公告）日：1994-08-10

  New use for 5-substitued ornithine derivatives for the preparation of a pharmaceutical composition for the treatment of dementia of the Alzheimer's type.

  5-取代鸟氨酸衍生物在制备治疗阿尔茨海默型痴呆症的药物组合物中的新用途。
• Increasing ornithine accumulation to increase high mannose glycoform content of recombinant proteins
  申请人：Amgen Inc.

  公开号：US11254963B2

  公开（公告）日：2022-02-22

  The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.

  本发明涉及一种在细胞培养过程中通过调节鸟氨酸代谢来控制重组糖蛋白的高甘露糖苷酸含量的方法。
• SELECTIVE INHIBITION OF GLUTAMINASE BY BIS-THIADIAZOLES
  申请人：——

  公开号：US20020115698A1

  公开（公告）日：2002-08-22

  Compounds are disclosed which efficiently inhibit glutaminase but which have no effect, at higher levels, on various mechanistically and functionally related enzymes. The compounds, which are useful for neuroprotection and in treatment of hepatic encephalopathy, have the general formula I: 1 as defined further herein.

  已公开的化合物能有效抑制谷氨酰胺酶，但在较高水平上对各种机制和功能相关的酶没有影响。这些化合物可用于神经保护和肝性脑病的治疗，其通式为 I： 1 如本文进一步定义。