N-Methyl-2-oxocycloheptane-1-sulfonamide | 143365-85-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N-Methyl-2-oxocycloheptane-1-sulfonamide
• 英文别名: N-methyl-2-oxocycloheptane-1-sulfonamide
• CAS: 143365-85-9
• 化学式: C₈H₁₅NO₃S
• 分子量: 205.278
• InChiKey: NWFDOGUYYTZHIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲基氨基磺酰氯 、 环庚烯-1-氧基(三甲基)硅烷 在 三乙胺 作用下， 以 乙腈 为溶剂， 以61%的产率得到N-Methyl-2-oxocycloheptane-1-sulfonamide
  参考文献：
  名称：

  Improved method for the synthesis of N-methyl-2-oxoalkanesulfonamides.

  摘要：

  A series of N-methyl-2-oxoalkanesulfonamides was prepared by reaction between silyl enol ethers and N-methylsulfonylimine. In all cases yields were comparatively higher to those obtained by a previously described procedure

  DOI：

  10.1016/s0040-4039(00)92534-6

文献信息

• Improved method for the synthesis of N-methyl-2-oxoalkanesulfonamides.
  作者：Juan A. Vega、Andrés Molina、Ramón Alajarín、Juan J. Vaquero、José L.García Navío、Julio Alvarez-Builla

  DOI：10.1016/s0040-4039(00)92534-6

  日期：1992.6

  A series of N-methyl-2-oxoalkanesulfonamides was prepared by reaction between silyl enol ethers and N-methylsulfonylimine. In all cases yields were comparatively higher to those obtained by a previously described procedure
• Synthesis and reactivity of N-alkyl-2-oxoalkanesulfonamides
  作者：Juan A. Vega、Ramón Alajarín、Juan J. Vaquero、Julio Alvarez-Builla

  DOI：10.1016/s0040-4020(98)00093-3

  日期：1998.4

  A series of N-alkyl-2-oxoalkanesulfonamides have been synthesized by reacting silyl enol ethers with N-alkyl-sulfamoyl chlorides. Their reactivity towards electrophiles was investigated in order to explore the regio-and stereoselectivity of the process. 2-Oxoalkanesulfonamides were used to prepare 5-(methylsulfamoyl)-1,4-dihydropyridines derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.