bis-(3-fluoro-2-(2-pivaloylaminophen-1-yl)quinol-4-yl)methanol | 250740-00-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: bis-(3-fluoro-2-(2-pivaloylaminophen-1-yl)quinol-4-yl)methanol
• 英文别名: N-[2-[4-[[2-[2-(2,2-dimethylpropanoylamino)phenyl]-3-fluoroquinolin-4-yl]-hydroxymethyl]-3-fluoroquinolin-2-yl]phenyl]-2,2-dimethylpropanamide
• CAS: 250740-00-2
• 化学式: C₄₁H₃₈F₂N₄O₃
• 分子量: 672.775
• InChiKey: KKZHVLUTAYZZHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  50
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  bis-(3-fluoro-2-(2-pivaloylaminophen-1-yl)quinol-4-yl)methanol 在 manganese(IV) oxide 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以72%的产率得到bis-(3-fluoro-2-(2-pivaloylaminophen-1-yl)quinol-4-yl)oxomethane
  参考文献：
  名称：

  First total synthesis of cryptomisrine

  摘要：

  The first total synthesis of cryptomisrine, a novel indolo[3,2-b]quinoline dimeric alkaloid from Cryptolepis sanguinolenta, is reported. The approach is based on a convergent methodology which involves a new halogen-dance reaction in quinoline series connected to a cross-coupling reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00715-2
• 作为产物：
  描述：

  3-氟喹啉 在 四(三苯基膦)钯 potassium carbonate 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙醇 、 甲苯 为溶剂， 反应 58.0h， 生成 bis-(3-fluoro-2-(2-pivaloylaminophen-1-yl)quinol-4-yl)methanol
  参考文献：
  名称：

  First total synthesis of cryptomisrine

  摘要：

  The first total synthesis of cryptomisrine, a novel indolo[3,2-b]quinoline dimeric alkaloid from Cryptolepis sanguinolenta, is reported. The approach is based on a convergent methodology which involves a new halogen-dance reaction in quinoline series connected to a cross-coupling reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00715-2

文献信息

• First total synthesis of cryptomisrine
  作者：Erwan Arzel、Patrick Rocca、Francis Marsais、Alain Godard、Guy Quéguiner

  DOI：10.1016/s0040-4020(99)00715-2

  日期：1999.10

  The first total synthesis of cryptomisrine, a novel indolo[3,2-b]quinoline dimeric alkaloid from Cryptolepis sanguinolenta, is reported. The approach is based on a convergent methodology which involves a new halogen-dance reaction in quinoline series connected to a cross-coupling reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.