3-ethyl-3-methyl-2-oxo-valeric acid | 90113-74-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 3-ethyl-3-methyl-2-oxo-valeric acid
• 英文别名: 3-Aethyl-3-methyl-2-oxo-valeriansaeure；3-Ethyl-3-methyl-2-oxopentanoic acid
• CAS: 90113-74-9
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: AGBWMIQALZHAHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-乙基-3-甲基-2-戊酮 在 sodium hydroxide 、 potassium permanganate 作用下， 生成 3-ethyl-3-methyl-2-oxo-valeric acid
  参考文献：
  名称：

  Wiemann; Sa-Lethi Thuan, Bulletin de la Societe Chimique de France, 1959, p. 1537

  摘要：

  DOI：

文献信息

• METHOD FOR PREPARING OPTICALLY ACTIVE AMINO ACID USING COSUBSTRATE SHUTTLING OF TRANSAMINASE
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

  公开号：US20150284750A1

  公开（公告）日：2015-10-08

  The present disclosure relates to a method for preparing an optically active amino acid using cosubstrate shuttling of transaminase. The method includes coupling a reaction of converting a keto acid to an amino acid by α-transaminase and a reaction of transferring an amino group of an amine substrate by ω-transaminase (TA) using an amino acid cosubstrate. The present disclosure allows production of various optically active amino acids with high purity and high efficiency by solving the low equilibrium constant problem of transaminase and is applicable to production of various optically active amino acids in industrial scale. Since the present disclosure allows easy production of various unnatural amino acids having high reactivity and stability, which are used as pharmaceutical precursors, it can be usefully employed in preparation of pharmaceuticals, food additives and various animal feeds.

  本公开涉及使用共基底穿梭转氨酶的方法制备光学活性氨基酸。该方法包括使用氨基酸共基底耦合α-转氨酶将酮酸转化为氨基酸的反应和使用ω-转氨酶（TA）转移胺基底物的胺基的反应。本公开解决了转氨酶低平衡常数问题，可高效高纯度地生产各种光学活性氨基酸，并适用于工业规模生产。由于本公开允许轻松生产具有高反应性和稳定性的各种非天然氨基酸，这些氨基酸可用作制药前体，因此可以在制备药物、食品添加剂和各种动物饲料方面得到有用的应用。
• MICROCAPSULES CONTAINING A GAS-GENERATING PHOTOLABILE KETOACID OR KETOESTER AND USES THEREOF
  申请人：FIRMENICH SA

  公开号：US20160108346A1

  公开（公告）日：2016-04-21

  The present invention relates to water-dispersable microcapsules comprising an oil phase, e.g. a perfume, containing a photolabile α-ketoacid or α-ketoester capable of generating a gas upon exposure to light. The gas is able to cause an extension or the breaking of the microcapsule allowing the release of the oil phase and thus increasing the long-lastingness of the odor perception. The present invention concerns also the use of said microcapsules in perfumery as well as the perfuming compositions or perfumed articles comprising the invention's microcapsules to provide a prolonged release of fragrant molecules.

  本发明涉及水分散微囊，包括油相，例如香料，其中包含光敏的α-酮酸或α-酮酯，能够在光照下产生气体。该气体能够引起微囊的扩张或破裂，释放油相，从而增加气味感知的持久性。本发明还涉及将所述微囊用于香料以及包含本发明微囊的香料组合物或带有香气的物品，以提供芳香分子的长时间释放。
• RESORBABLE POLYMERIC MEDICAL GOODS WITH IMPROVED MECHANICAL PROPERTIES AND METHOD FOR PRODUCING SAME
  申请人：Synthes GmbH

  公开号：EP1744792A1

  公开（公告）日：2007-01-24
• US8211351B2
  申请人：——

  公开号：US8211351B2

  公开（公告）日：2012-07-03
• US9376694B2
  申请人：——

  公开号：US9376694B2

  公开（公告）日：2016-06-28