3-phenyl-2-[(pyridine-2-carbonyl)-amino]-propionic acid | 200435-06-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-phenyl-2-[(pyridine-2-carbonyl)-amino]-propionic acid
• 英文别名: 3-Phenyl-2-(pyridine-2-carbonylamino)propanoic acid
• CAS: 200435-06-9
• 化学式: C₁₅H₁₄N₂O₃
• 分子量: 270.288
• InChiKey: IBVLHTOLKDMNPX-UHFFFAOYSA-N

物化性质

• 沸点：
  561.3±45.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 3-phenyl-2-(picolinamido)propanoate 在 lithium hydroxide monohydrate 作用下， 以 甲醇 为溶剂， 生成 3-phenyl-2-[(pyridine-2-carbonyl)-amino]-propionic acid
  参考文献：
  名称：

  Trifunctional N,N,O-Terdentate Amido/Pyridyl Carboxylate Ligated Pd(II) Complexes for Heck and Suzuki Reactions

  摘要：

  Trifunctional N,N,O-terdentate amido/pyridyl carboxylate Pd(II) complexes were highly active and stable phosphine-free catalysts for Heck and room-temperature Suzuki reactions with high turnover numbers tip to ca. 10(4).

  DOI：

  10.1021/jo900361c

文献信息

• [EN] TREATMENT FOR LIVER REGENERATION<br/>[FR] TRAITEMENT DE RÉGÉNÉRATION DU FOIE
  申请人：XENEXUS PHARMACEUTICALS PTY LTD

  公开号：WO2020014726A1

  公开（公告）日：2020-01-23

  Disclosed are pharmaceutical compositions comprising rebamipide together with one or more pharmaceutically acceptable carriers, diluents and excipients. Methods for use of the said compositions for increasing liver regeneration after partial hepatectomy and following liver transplantation to prevent postoperative liver failure and in the treatment of acute and chronic lilver failure are also disclosed.
• Trifunctional <i>N</i>,<i>N</i>,<i>O</i>-Terdentate Amido/Pyridyl Carboxylate Ligated Pd(II) Complexes for Heck and Suzuki Reactions
  作者：M. Lakshmi Kantam、P. Srinivas、Jagjit Yadav、Pravin R. Likhar、Suresh Bhargava

  DOI：10.1021/jo900361c

  日期：2009.7.3

  Trifunctional N,N,O-terdentate amido/pyridyl carboxylate Pd(II) complexes were highly active and stable phosphine-free catalysts for Heck and room-temperature Suzuki reactions with high turnover numbers tip to ca. 10(4).