spiro[7-hydroxy-3,4-dihydrochroman-2,4'-(3'-p-toluenesufonyl)oxazolidin]-2'-one | 1210042-90-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: spiro[7-hydroxy-3,4-dihydrochroman-2,4'-(3'-p-toluenesufonyl)oxazolidin]-2'-one
• 英文别名: 7'-Hydroxy-3-(4-methylphenyl)sulfonylspiro[1,3-oxazolidine-4,2'-3,4-dihydrochromene]-2-one；7'-hydroxy-3-(4-methylphenyl)sulfonylspiro[1,3-oxazolidine-4,2'-3,4-dihydrochromene]-2-one
• CAS: 1210042-90-2
• 化学式: C₁₈H₁₇NO₆S
• 分子量: 375.402
• InChiKey: IDOYBRSKCLYSCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-vinylidene-1,3-oxazolidin-2-one 、 间苯二酚 在 双三氟甲烷磺酰亚胺 作用下， 以 二氯甲烷 为溶剂， 以59%的产率得到spiro[7-hydroxy-3,4-dihydrochroman-2,4'-(3'-p-toluenesufonyl)oxazolidin]-2'-one
  参考文献：
  名称：

  Synthesis of Functionalized Chromanes via a Formal [3+3]Cycloaddition of Allene Sulfonamides to Phenols

  摘要：

  The Bronsted acid catalyzed formal [3 + 3] cycloaddition reaction of allene sulfonamides l with phenols 2 provides functionalized chromanes. This formal [3 + 3] cycloaddition reaction is proposed to proceed via a stepwise process involving intermolecular hydroarylation followed by intramolecular cyclization.

  DOI：

  10.3987/com-09-s(s)54

文献信息

• Synthesis of Functionalized Chromanes via a Formal [3+3]Cycloaddition of Allene Sulfonamides to Phenols
  作者：Shigeyasu Kuroda、Yoshikazu Horino、Ken Hashimoto

  DOI：10.3987/com-09-s(s)54

  日期：——

  The Bronsted acid catalyzed formal [3 + 3] cycloaddition reaction of allene sulfonamides l with phenols 2 provides functionalized chromanes. This formal [3 + 3] cycloaddition reaction is proposed to proceed via a stepwise process involving intermolecular hydroarylation followed by intramolecular cyclization.