3-hydroxyphenyl palmitate | 224455-12-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 3-hydroxyphenyl palmitate
• 英文别名: (3-Hydroxyphenyl) hexadecanoate
• CAS: 224455-12-3
• 化学式: C₂₂H₃₆O₃
• 分子量: 348.526
• InChiKey: KOZKAYNRSNWXHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  25
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxyphenyl palmitate 在 palladium on activated charcoal 四氮唑 、 氢气 、 双氧水 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 Hexadecanoic acid 3-phosphonooxy-phenyl ester
  参考文献：
  名称：

  Structure−Activity Relationships of Lysophosphatidic Acid:  Conformationally Restricted Backbone Mimetics

  摘要：

  Lysophosphatidic acid (LPA) has associated with it an intriguing cell biology that is thought to be mediated through its interaction with G-protein coupled receptor(s). In an effort to extend the structure-activity relationships of LPA, we have produced a series of LPA analogues in which the glycerol core in LPA was replaced with conformationally restricted aryl substructures. The aryl substructures encompassed aminophenol, resorcinol, dihydroxy benzophenone, and tocopherol systems. The benzophenone moiety was investigated both as a conformationally restricting substructure for LPA and as a possible photoreactive alkylating agent for the LPA receptor(s). All LPA analogues were evaluated for their potency and efficacy in mobilizing calcium ions from internal stores in MDA MB-231 cells. Ten of the 14 analogues exhibited activity in this assay at doses up to 5 mu M; none of the compounds exhibited nonreceptor-mediated lytic activity at this maximal concentration. The receptor response showed surprising tolerance for manipulation in the backbone region of LPA, although none of the compounds were equipotent to LPA. This tolerance for a variety of structures has given us new leads into the realization of novel agonists and antagonists of the LPA receptor(s).

  DOI：

  10.1021/jm970809v
• 作为产物：
  描述：

  间苯二酚 、 棕榈酰氯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 以36%的产率得到3-hydroxyphenyl palmitate
  参考文献：
  名称：

  Structure−Activity Relationships of Lysophosphatidic Acid:  Conformationally Restricted Backbone Mimetics

  摘要：

  Lysophosphatidic acid (LPA) has associated with it an intriguing cell biology that is thought to be mediated through its interaction with G-protein coupled receptor(s). In an effort to extend the structure-activity relationships of LPA, we have produced a series of LPA analogues in which the glycerol core in LPA was replaced with conformationally restricted aryl substructures. The aryl substructures encompassed aminophenol, resorcinol, dihydroxy benzophenone, and tocopherol systems. The benzophenone moiety was investigated both as a conformationally restricting substructure for LPA and as a possible photoreactive alkylating agent for the LPA receptor(s). All LPA analogues were evaluated for their potency and efficacy in mobilizing calcium ions from internal stores in MDA MB-231 cells. Ten of the 14 analogues exhibited activity in this assay at doses up to 5 mu M; none of the compounds exhibited nonreceptor-mediated lytic activity at this maximal concentration. The receptor response showed surprising tolerance for manipulation in the backbone region of LPA, although none of the compounds were equipotent to LPA. This tolerance for a variety of structures has given us new leads into the realization of novel agonists and antagonists of the LPA receptor(s).

  DOI：

  10.1021/jm970809v

文献信息

• Coloring composition for color filters containing microencapsulated pigment composed of polyhydroxyalkanoate
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20030203458A1

  公开（公告）日：2003-10-30

  The invention provides coloring composition for color filters making use of a pigment, in which the dispersed state of the pigment is stable without using any surfactant, and so aggregation is hard to occur, and which permits formation of high-definition and high-quality images excellent in color rendition, transparency and contrast, and a simple production process thereof, by which the use of surfactants can be abolished, or the amount of surfactants used can be reduced to a great extent. The coloring composition for color filters is provided by using at least a coloring material obtained by coating at least part of surfaces of pigment particles with polyhydroxyalkanoate, and a dispersion medium for the coloring material.

  该发明提供了一种用于彩色滤光片的染色组合物，其中颜料的分散状态稳定，不需要使用任何表面活性剂，因此聚集很难发生，并且允许形成高清晰度和高质量的图像，具有出色的色彩再现度、透明度和对比度，以及简单的生产过程，通过该过程可以废除表面活性剂的使用，或者大大减少所使用的表面活性剂的数量。通过使用至少一种染色材料，该染色材料通过在颜料颗粒的至少一部分表面上涂覆聚羟基烷酸酯而获得，并且用于染色材料的分散介质。
• Coloring composition containing a pigment coated by a polyhydroxyalkanoate
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1262229A1

  公开（公告）日：2002-12-04

  The invention provides coloring composition for color filters making use of a pigment, in which the dispersed state of the pigment is stable without using any surfactant, and so aggregation is hard to occur, and which permits formation of high-definition and high-quality images excellent in color rendition, transparency and contrast, and a simple production process thereof, by which the use of surfactants can be abolished, or the amount of surfactants used can be reduced to a great extent. The coloring composition for color filters is provided by using at least a coloring material obtained by coating at least part of surfaces of pigment particles with polyhydroxyalkanoate, and a dispersion medium for the coloring material.

  本发明提供了使用颜料的彩色滤光片用着色组合物，在该组合物中，颜料的分散状态稳定，无需使用任何表面活性剂，因此不易发生聚集，可形成色彩还原性、透明度和对比度极佳的高清晰度和高质量图像，而且其生产工艺简单，可以不使用表面活性剂，或大大减少表面活性剂的用量。该彩色滤光片的着色组合物至少使用了一种通过在颜料颗粒的至少部分表面涂覆聚羟基烷酸酯而获得的着色材料，以及一种用于该着色材料的分散介质。
• Structure−Activity Relationships of Lysophosphatidic Acid:  Conformationally Restricted Backbone Mimetics
  作者：Darrin W. Hopper、Seamus P. Ragan、Shelley B. Hooks、Kevin R. Lynch、Timothy L. Macdonald

  DOI：10.1021/jm970809v

  日期：1999.3.1

  Lysophosphatidic acid (LPA) has associated with it an intriguing cell biology that is thought to be mediated through its interaction with G-protein coupled receptor(s). In an effort to extend the structure-activity relationships of LPA, we have produced a series of LPA analogues in which the glycerol core in LPA was replaced with conformationally restricted aryl substructures. The aryl substructures encompassed aminophenol, resorcinol, dihydroxy benzophenone, and tocopherol systems. The benzophenone moiety was investigated both as a conformationally restricting substructure for LPA and as a possible photoreactive alkylating agent for the LPA receptor(s). All LPA analogues were evaluated for their potency and efficacy in mobilizing calcium ions from internal stores in MDA MB-231 cells. Ten of the 14 analogues exhibited activity in this assay at doses up to 5 mu M; none of the compounds exhibited nonreceptor-mediated lytic activity at this maximal concentration. The receptor response showed surprising tolerance for manipulation in the backbone region of LPA, although none of the compounds were equipotent to LPA. This tolerance for a variety of structures has given us new leads into the realization of novel agonists and antagonists of the LPA receptor(s).