N'-[(1E)-(3,4,5-trimethoxyphenyl)methylidene]pyrazine-2-carbohydrazide | 1239766-77-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N'-[(1E)-(3,4,5-trimethoxyphenyl)methylidene]pyrazine-2-carbohydrazide
• 英文别名: LASSBio-1181；N'-[(E)-(3,4,5-trimethoxyphenyl)methylidene]-2-pyrazinecarbohydrazide；N-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]pyrazine-2-carboxamide
• CAS: 1239766-77-8
• 化学式: C₁₅H₁₆N₄O₄
• 分子量: 316.316
• InChiKey: FPBWXDUKTWKNMF-QGMBQPNBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  94.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  吡嗪-2-甲酰肼 、 3,4,5-三甲氧基苯甲醛 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以73%的产率得到N'-[(1E)-(3,4,5-trimethoxyphenyl)methylidene]pyrazine-2-carbohydrazide
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates

  摘要：

  In this paper, we report the synthesis and pharmacological evaluation of pyrazine N-acylhydrazone (NAH) derivatives (2a-s) designed as novel analgesic and anti-inflammatory drug candidates. This series was planned by molecular simplification of prototype 1 (LASSBio-1018), previously described as a nonselective cyclooxygenase inhibitor. Derivatives 2a-s were evaluated in several animal models of pain and inflammation, standing-out compound 2o (2-N'-[(E)-(3,4,5-trimethoxyphenyl) methylidene]-2-pyrazinecarbohydrazide; LASSBio-1181), that was also active in a murine model of chronic inflammation (i.e., adjuvant-induced arthritis test in rats) and can be considered a new analgesic and anti-inflammatory lead for drug development. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.06.002