6-(2,6-Dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one | 305820-75-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 6-(2,6-Dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one
• CAS: 305820-75-1
• 化学式: C₂₄H₂₁Cl₂N₅O₂
• 分子量: 482.4
• InChiKey: XZEJMVDCQZRHLN-UHFFFAOYSA-N

物化性质

• 熔点：
  >280oC (dec.)
• 沸点：
  693.0±65.0 °C(Predicted)
• 密度：
  1.422±0.06 g/cm3(Predicted)
• 溶解度：
  二甲基亚砜：>10mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  70.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection
  申请人：Emory University

  公开号：EP2233174A1

  公开（公告）日：2010-09-29

  Compositions and methods are provided for using tyrosine kinase inhibitors to treat pathogenic infection. In particular, methods for using Abl-family tyrosine kinase inhibitors to treat pathogenic infection are provided. Infections to be treated according to the present invention include, particularly, those caused by microbial pathogens such as bacteria and viruses.

  提供了使用酪氨酸激酶抑制剂治疗致病性感染的组合物和方法。特别是提供了使用 Abl 家族酪氨酸激酶抑制剂治疗病原体感染的方法。根据本发明要治疗的感染尤其包括由细菌和病毒等微生物病原体引起的感染。
• FMO3 inhibitors for treating pain
  申请人：Akron Molecules GmbH

  公开号：EP2674161A1

  公开（公告）日：2013-12-18

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.

  本发明涉及治疗疼痛和相关疾病的新疗法，以及用于上述疗法的药物化合物。
• Neurofibromatoses therapeutic agents and screening for same
  申请人：Fernandez-Valle Cristina

  公开号：US10105351B2

  公开（公告）日：2018-10-23

  Disclosed herein are methods of treating a patient at risk of developing or having a neurofibromatosis or a sporadic schwannoma. In exemplary embodiments, the method involves administering to a subject in need an effective amount of a modulator of a target related to neurofibromatosis. Also disclosed are screening assays involving the implementation of Merlin-null Schwann cells, and to compounds identified using same.

  本文公开了治疗有患神经纤维瘤病或散发性分裂瘤风险的患者的方法。在示例性实施方案中，该方法涉及向有需要的受试者施用有效量的神经纤维瘤病相关靶点的调节剂。还公开了涉及实施Merlin-null许旺细胞的筛选试验，以及利用这些试验鉴定的化合物。
• NEUROFIBROMATOSES THERAPEUTIC AGENTS AND SCREENING FOR SAME
  申请人：University of Central Florida Research Foundation, Inc.

  公开号：EP2825209B1

  公开（公告）日：2018-08-29
• Compounds and Methods for Treating Pain
  申请人：Penninger Josef

  公开号：US20130252924A1

  公开（公告）日：2013-09-26

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.