胆甾-5-烯,3-(十四烷氧基)-,(3b)-(9CI) | 126128-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 胆甾-5-烯,3-(十四烷氧基)-,(3b)-(9CI)
• 中文别名: 6H,8H-3,4-二氢嘧啶并(4,5-c)(1,2)恶嗪-7-酮
• 英文名称: 6H,8H-3,4-Dihydropyrimido(4,5-c)(1,2)oxazin-7-one
• 英文别名: 1,3,4,8-tetrahydropyrimido[4,5-c]oxazin-7-one
• CAS: 126128-35-6
• 化学式: C₆H₇N₃O₂
• 分子量: 153.14
• InChiKey: OQCFWECOQNPQCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  62.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in composition and use thereof
  申请人：Li Xiaodong

  公开号：US20090274632A1

  公开（公告）日：2009-11-05

  The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  本发明涉及发现T2R味觉受体家族中特定人类味觉受体对咖啡等中特定苦味化合物的反应。此外，本发明涉及发现特定化合物和含有该化合物的组合物作为苦味阻断剂的功能，以及将其用作苦味阻断剂或调味剂，例如在咖啡和咖啡味食品、饮料和药品中。此外，本发明涉及发现一种对抗多种不同人类T2R的化合物，并将其用于检测中以及作为人类和动物摄入的组合物中的苦味阻断剂。
• P2X7 MODULATORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20150322062A1

  公开（公告）日：2015-11-12

  The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.

  本发明涉及公式（I，IIa和IIb）的化合物：本发明还涉及包括公式（I，IIa和IIb）的化合物的制药组合物。制备和使用公式（I，IIa和IIb）的方法也在本发明的范围内。
• Compounds that inhibit (block) bitter taste in composition and methods of making same
  申请人：LI Xiaodong

  公开号：US20110207937A1

  公开（公告）日：2011-08-25

  The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  本发明涉及发现T2R味觉受体家族中的特定人类味觉受体对存在于咖啡等物质中的特定苦味化合物做出反应。此外，本发明还涉及发现特定化合物和含有该化合物的组合物，其作为苦味味觉阻滞剂的功能以及在咖啡和咖啡味食品、饮料和药品中作为苦味味觉阻滞剂或风味调节剂的使用。此外，本发明还涉及发现一种拮抗多种不同人类T2R的化合物，以及在人类和动物摄入的组合物中作为苦味味觉阻滞剂的使用和试验。
• COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND USE THEREOF
  申请人：KARANEWSKY Donald S.

  公开号：US20120088796A1

  公开（公告）日：2012-04-12

  The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  本发明涉及到的发现是特定的人类味觉受体T2R味觉受体家族对于存在于咖啡中的特定苦味化合物做出反应。此外，本发明涉及到的发现是特定的化合物和含有这些化合物的组合物，作为苦味阻滞剂或调味剂在例如咖啡和咖啡味食品、饮料和药品中的使用。此外，本发明涉及到的发现是一种拮抗多种不同人类T2R的化合物，其在人类和动物摄入的组合物中可用作测定和苦味阻滞剂。
• Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
  申请人：Karanewsky Donald S.

  公开号：US20100254916A1

  公开（公告）日：2010-10-07

  The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  本发明涉及发现人类T2R味觉受体家族中特定的味觉受体对咖啡等中的特定苦味化合物产生反应。此外，本发明还涉及特定化合物和含有该化合物的组合物的发现，其作为苦味阻断剂的功能，并且可以在咖啡和咖啡风味食品、饮料和药物中用作苦味阻断剂或风味调节剂。此外，本发明还涉及发现一种对多种不同的人类T2R产生拮抗作用的化合物，并且可以在人类和动物摄入的组合物中用作苦味阻断剂以及用于检测的用途。