4-[2,5-dimethyl-3-(2-(1-pyrrolidinyl)acetyl)-1-pyrrolyl]chlorobenzene | 379237-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-[2,5-dimethyl-3-(2-(1-pyrrolidinyl)acetyl)-1-pyrrolyl]chlorobenzene
• 英文别名: 1-[1-(4-Chlorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone
• CAS: 379237-39-5
• 化学式: C₁₈H₂₁ClN₂O
• 分子量: 316.831
• InChiKey: OQFKCACNJXVXIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Compositions and methods for enhancing proteasome activity
  申请人：President and Fellows of Harvard College

  公开号：US10351568B2

  公开（公告）日：2019-07-16

  Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.

  蛋白病症是由于蛋白酶体不能有效地消除有害蛋白质并防止致病聚集体的形成。如本文所述，抑制蛋白酶体相关的去泛素化酶 Usp14 可提高蛋白酶体的效率。因此，本发明提供了抑制 Usp14、增强蛋白酶体活性和治疗蛋白质病的新型组合物和方法。
• COMPOSITIONS AND METHODS FOR ENHANCING PROTEASOME ACTIVITY
  申请人：President and Fellows of Harvard College

  公开号：EP2528911B1

  公开（公告）日：2017-10-25
• Compositions and Methods for Enhancing Proteasome Activity
  申请人：Finley Daniel J.

  公开号：US20130045992A1

  公开（公告）日：2013-02-21

  Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp 14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
• US20140275169A1
  申请人：——

  公开号：US20140275169A1

  公开（公告）日：2014-09-18
• USP14 Inhibitors for Treating or Preventing Viral Infections
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20150335652A1

  公开（公告）日：2015-11-26

  Disclosed herein are methods of treating or preventing a viral infection resulting from infection by a flavivirus, comprising administering to a subject a small molecule inhibitor of USP14, represented by Formula (I) or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, chemically-protected form, enantiomer or stereoisomer thereof, and pharmaceutical compositions comprising an effective amount of a compound of Formula (I) for use in the method.