methyl (2S)-2-[[chloro(ethenyl)phosphoryl]-prop-2-enylamino]-3-phenylpropanoate | 345898-58-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-[[chloro(ethenyl)phosphoryl]-prop-2-enylamino]-3-phenylpropanoate
• CAS: 345898-58-0
• 化学式: C₁₅H₁₉ClNO₃P
• 分子量: 327.748
• InChiKey: XAXVIIWZKBASKV-YXWRBFHGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl (2S)-2-[[chloro(ethenyl)phosphoryl]-prop-2-enylamino]-3-phenylpropanoate 在 Grubbs catalyst first generation 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 (S)-2-{(S)-2-[(R)-1-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-2-oxo-2,5-dihydro-1H-2λ⁵-[1,2]azaphosphol-2-yloxy]-2-oxo-2,5-dihydro-2λ⁵-[1,2]azaphosphol-1-yl}-3-phenyl-propionic acid methyl ester
  参考文献：
  名称：

  The Synthesis of P-Chiral Amino Acid-Derived Phosphonamidic Anhydrides

  摘要：

  The synthesis of an array of P-chiral amino acid-derived phosphonamidic anhydrides is described. These anhydrides are prepared by condensation of allylated amino acids 19-22 with methyl- or vinylphosphonic dichlorides 23 or 24 to produce three diastereomeric anhydrides 4-11a-c in good to excellent yields. The mechanistic issues concerning anhydride formation are discussed and supported by experimental results. Vinylphosphonamidic anhydrides 8-11 are further derivatized via the ring-closing metathesis (RCM) reaction to yield amino acid-derived bicyclic phosphonamidic anhydrides.

  DOI：

  10.1021/jo000631b
• 作为产物：
  描述：

  乙烯基膦酰氯 、 N-allylated phenylalanine methyl ester 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以99%的产率得到methyl (2S)-2-[[chloro(ethenyl)phosphoryl]-prop-2-enylamino]-3-phenylpropanoate
  参考文献：
  名称：

  Sprott; McReynolds; Hanson, Synthesis, 2001, # 4, p. 612 - 620

  摘要：

  DOI：

文献信息

• Sprott; McReynolds; Hanson, Synthesis, 2001, # 4, p. 612 - 620
  作者：Sprott、McReynolds、Hanson

  DOI：——

  日期：——
• The Synthesis of <i>P</i>-Chiral Amino Acid-Derived Phosphonamidic Anhydrides
  作者：Kevin T. Sprott、Paul R. Hanson

  DOI：10.1021/jo000631b

  日期：2000.7.1

  The synthesis of an array of P-chiral amino acid-derived phosphonamidic anhydrides is described. These anhydrides are prepared by condensation of allylated amino acids 19-22 with methyl- or vinylphosphonic dichlorides 23 or 24 to produce three diastereomeric anhydrides 4-11a-c in good to excellent yields. The mechanistic issues concerning anhydride formation are discussed and supported by experimental results. Vinylphosphonamidic anhydrides 8-11 are further derivatized via the ring-closing metathesis (RCM) reaction to yield amino acid-derived bicyclic phosphonamidic anhydrides.