4-phenyl-N-(pyrazin-2-yl)pyrimidin-2-amine | 1236002-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-phenyl-N-(pyrazin-2-yl)pyrimidin-2-amine
• 英文别名: 4-phenyl-N-pyrazin-2-ylpyrimidin-2-amine
• CAS: 1236002-86-0
• 化学式: C₁₄H₁₁N₅
• 分子量: 249.275
• InChiKey: WSCXOWGEZGKKRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  氨基吡嗪 、 4-苯基-2-氯嘧啶 在 potassium phosphate 、 tris-(dibenzylideneacetone)dipalladium(0) 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 为溶剂， 反应 6.0h， 以45%的产率得到4-phenyl-N-(pyrazin-2-yl)pyrimidin-2-amine
  参考文献：
  名称：

  Convenient preparation of 4-aryl-2-(heteroarylamino)pyrimidines and 4-anilino-2-(heteroarylamino)pyrimidines

  摘要：

  4-Aryl-2-anilinopyrimidines and 2,4-dianilinopyrimidines are privileged structures found in many drug-like molecules and biologically active compounds. A method for the quick assembly of novel 4-aryl- and 4-anilino-2-(heteroarylamino)pyrimidines via Buchwald-Hartwig N-arylations at elevated temperatures under sealed tube conditions is reported. This method's convenience and practicality is demonstrated through the preparation of several novel non-nucleoside reverse transcriptase inhibitor (NNRTI) analogues. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.062

文献信息

• Convenient preparation of 4-aryl-2-(heteroarylamino)pyrimidines and 4-anilino-2-(heteroarylamino)pyrimidines
  作者：Brian I. Bliss、Feryan Ahmed、Subashree Iyer、Weimin Lin、Joel Walker、He Zhao

  DOI：10.1016/j.tetlet.2010.04.062

  日期：2010.6

  4-Aryl-2-anilinopyrimidines and 2,4-dianilinopyrimidines are privileged structures found in many drug-like molecules and biologically active compounds. A method for the quick assembly of novel 4-aryl- and 4-anilino-2-(heteroarylamino)pyrimidines via Buchwald-Hartwig N-arylations at elevated temperatures under sealed tube conditions is reported. This method's convenience and practicality is demonstrated through the preparation of several novel non-nucleoside reverse transcriptase inhibitor (NNRTI) analogues. (C) 2010 Elsevier Ltd. All rights reserved.