7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-4E-hepten-3-one | 79559-60-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-4E-hepten-3-one
• 英文别名: 7-(4''-hydroxy-3''-methoxyphenyl)-1-phenylhept-4-en-3-one；(4E)-7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one；(E)-7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one
• CAS: 79559-60-7
• 化学式: C₂₀H₂₂O₃
• 分子量: 310.393
• InChiKey: NOHMOWQGVDSLNY-UXBLZVDNSA-N

物化性质

• 沸点：
  499.4±45.0 °C(Predicted)
• 密度：
  1.113±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (E)-7-(3-methoxy-4-((triisopropylsilyl)oxy)phenyl)-1-phenylhept-4-en-3-one 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以82%的产率得到7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-4E-hepten-3-one
  参考文献：
  名称：

  通过 Au(I) 催化的 Meyer-Schuster 重排高效全合成三种阿尔卑斯类化合物

  摘要：

  报道了三种结构相关的天然产物：脱氧alpinoid B、脱氧alpinoid A和alpinoid F的全合成，并且每种都以Au(I)催化的Meyer-Schuster重排为关键步骤。 Alpinoid F的合成为首次报道。这些天然产物的合成均表现出有效的抗癌活性，并且易于制备结构类似物。

  DOI：

  10.1016/j.tetlet.2022.154015

文献信息

• Clonidine to treat pain locally
  申请人：Medtronic, Inc.

  公开号：EP2363122A1

  公开（公告）日：2011-09-07

  The present invention is directed to systems and methods for contributing to the local treatment of pain. More specifically, the present invention is directed to the use of one or more NFKB inhibiting compounds, particularly clonidine, in the manufacture of a medicament for the treatment of pain wherein said medicament is for local administration to a patient in need thereof.

  本发明涉及有助于局部治疗疼痛的系统和方法。更具体地说，本发明涉及将一种或多种 NFKB 抑制化合物，特别是氯硝柳胺，用于制造治疗疼痛的药物，其中所述药物用于对有需要的患者进行局部给药。
• Reduced sodium food products
  申请人：GENERAL MILLS, INC.

  公开号：US10159268B2

  公开（公告）日：2018-12-25

  Naturally-derived compounds having various structures elicit the perception of salty taste, enhance the perception of salty taste of a salt, or act at one or more sodium channels. Food products may include such naturally-derived compounds, which may be used to reduce the sodium content, while imparting a similar level of saltiness.

  具有各种结构的天然衍生化合物可引起咸味感知、增强盐的咸味感知或作用于一个或多个钠通道。食品中可能含有此类天然萃取化合物，可用于降低钠含量，同时提供类似的咸味。
• Diarylheptanoid compounds and uses thereof
  申请人：Rafi M. Mohamed

  公开号：US20050215635A1

  公开（公告）日：2005-09-29

  The present invention relates to diarylheptanoid compounds and compositions comprising a diarylheptanoid compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more diarylheptanoid compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more diarylheptanoid compounds. The present invention further relates to articles of manufacture comprising one or more diarylheptanoid compounds.

  本发明涉及二芳基庚烷类化合物和包含二芳基庚烷类化合物的组合物。本发明还涉及通过向有需要的受试者施用一种或多种二芳基庚烷类化合物来预防或治疗各种疾病和失调的方法。特别是，本发明涉及通过向有需要的受试者施用一种或多种二芳基庚烷类化合物来预防或治疗癌症或炎症性疾病的方法。本发明还涉及包含一种或多种二芳基庚烷类化合物的制造品。
• Methods and reagents for the treatment of immunoinflammatory disorders
  申请人：Manivasakam Palaniyandi

  公开号：US20050271661A1

  公开（公告）日：2005-12-08

  The invention involves the treatment, prevention, and reduction of immunoinflammatory disorders involving the combination of an agent that increases the signal activity of a glucocorticoid receptor (e.g., glucocorticoid receptor agonist) and an agent that modulates the signaling activity of one or more signaling pathways selected from the NF-κB pathway, NFAT pathway, AP-1 pathway, and Elk-1 pathway such that proinflammatory cytokine secretion or production, or any other inflammatory response, is reduced. Further, screening methods are provided for identifying candidate compounds and strategies useful for treating, preventing, or reducing such conditions.

  本发明涉及免疫炎症性疾病的治疗、预防和减轻，包括将增加糖皮质激素受体信号活性的制剂（如糖皮质激素受体激动剂）和调节选自NF-κB通路、NFAT通路、AP-1通路和Elk-1通路的一种或多种信号通路的信号活性的制剂结合使用，从而减少促炎细胞因子的分泌或产生，或任何其他炎症反应。此外，还提供了用于识别候选化合物以及治疗、预防或减轻此类病症的策略的筛选方法。
• Systems and Methods to Treat Pain Locally
  申请人：Burright N. Eric

  公开号：US20060253100A1

  公开（公告）日：2006-11-09

  Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting the NFκB family of transcription factors.

  本文公开了有助于局部治疗疼痛的系统和方法。更具体地说，所公开的系统和方法通过抑制转录因子 NFκB 家族来促进疼痛的局部治疗。