(2S)-4-amino-2-[[(2R)-2-azaniumylpropanoyl]amino]-4-oxobutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-4-amino-2-[[(2R)-2-azaniumylpropanoyl]amino]-4-oxobutanoate
• 化学式: C7H13N3O4
• 分子量: 203.2
• InChiKey: CCUAQNUWXLYFRA-DMTCNVIQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Engineered alanyl-glutamine dipeptide biosynthetic enzyme and application thereof
  申请人：INNOBIO CORPORATION LIMITED

  公开号：US10865225B2

  公开（公告）日：2020-12-15

  Provided is a gene encoding alanyl-glutamine dipeptide biosynthetic enzyme and the application thereof. The nucleotide sequence of said gene is shown in SEQ ID NO: 1. Further, provided is an amino acid sequence encoded by the gene, and provided recombinant vector, recombinant E. coli, recombinant S. cerevisiae, and a self-flocculating recombinant S. cerevisiae containing the gene. Furthermore, provided is a method for carrying out bioconversion to synthesize alanyl-glutamine dipeptide by using said recombinant microorganisms. The application of the gene and recombinant batteries has the characteristics of high molar conversion rate, fast production rate and repeated recycling of the bacteria. It is a good choice for efficient, environmentally friendly and economical production of alanyl-glutamine dipeptide. In addition, through the recycling process, it is expected to reduce the cost of industrial production, solve the problems of difficult enzyme recovery, low utilization rate and unstable enzyme activity.

  提供了一种编码丙氨酰-谷氨酰胺二肽生物合成酶的基因及其应用。所述基因的核苷酸序列如 SEQ ID NO: 1 所示。此外，还提供了由该基因编码的氨基酸序列，并提供了含有该基因的重组载体、重组大肠杆菌、重组酿酒葡萄球菌和自絮凝重组酿酒葡萄球菌。此外，还提供了一种利用上述重组微生物进行生物转化合成丙氨酰-谷氨酰胺二肽的方法。该基因和重组电池的应用具有摩尔转化率高、生产速度快、细菌可反复循环利用等特点。是高效、环保、经济地生产丙氨酰-谷氨酰胺二肽的良好选择。此外，通过循环利用，有望降低工业生产成本，解决酶回收难、利用率低、酶活性不稳定等问题。
• GENE ENCODING ALANYL- GLUTAMINE DIPEPTIDE BIOSYNTHETIC ENZYME AND APPLICATION THEREOF
  申请人：INNOBIO CORPORATION LIMITED

  公开号：US20190315801A1

  公开（公告）日：2019-10-17

  Provided is a gene encoding alanyl-glutamine dipeptide biosynthetic enzyme and the application thereof. The nucleotide sequence of said gene is shown in SEQ ID NO: 1. Further, provided is an amino acid sequence encoded by the gene, and provided recombinant vector, recombinant E. coli , recombinant S. cerevisiae , and a self-flocculating recombinant S. cerevisiae containing the gene. Furthermore, provided is a method for carrying out bioconversion to synthesize alanyl-glutamine dipeptide by using said recombinant microorganisms. The application of the gene and recombinant batteries has the characteristics of high molar conversion rate, fast production rate and repeated recycling of the bacteria. It is a good choice for efficient, environmentally friendly and economical production of alanyl-glutamine dipeptide. In addition, through the recycling process, it is expected to reduce the cost of industrial production, solve the problems of difficult enzyme recovery, low utilization rate and unstable enzyme activity.