12-Hydroxy-5,8,10-heptadecatrienoic acid | 50683-78-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-Hydroxy-5,8,10-heptadecatrienoic acid
• 英文别名: (5E,8E,10E)-12-hydroxyheptadeca-5,8,10-trienoic acid
• CAS: 50683-78-8
• 化学式: C₁₇H₂₈O₃
• 分子量: 280.4
• InChiKey: KUKJHGXXZWHSBG-GMPNNLDHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (5E,8E,11E,14E)-(114C)icosa-5,8,11,14-tetraenoic acid 生成 12-Hydroxy-5,8,10-heptadecatrienoic acid
  参考文献：
  名称：

  KIMURA, YOSHIYUKI;OKUDA, HIROMICHI;OKUDA, TAKUO;HATANO, TSUTOMU;ARICHI, S+, J. NATUR. PROD., 50,(1987) N 3, 392-399

  摘要：

  DOI：

文献信息

• Compositions and methods for detecting and quantifying COX-2 activity and 2-arachidonylglycerol metabolites
  申请人：——

  公开号：US20020064804A1

  公开（公告）日：2002-05-30

  The present invention provides methods, compositions and kits for discriminating between COX-1 and COX-2 activity. In particular, the prevent invention provides for the detection and/or measurement of COX-2 activity in subjects, samples thereof, and in laboratory tests. The present invention discloses that 2-arachidonylglycerol is a COX-2 selective substrate which is metabolized by COX-2 to prostaglandin glycerol esters (PG-Gs) and that the diversity of PG-Gs parallels that of arachidonic acid derived metabolites of COX. The present invention also provides certain novel COX-2 selective metabolites including prostaglandin I 2 -glycerol ester (PGI 2 -G) and 6-keto-prostaglandin F 1&agr; -glycerol ester. Methods and kits are described for detecting COX-2 activity comprising detecting PG-Gs (including the novel PG-Gs disclosed herein). Uses for these methods and kits include the detection and monitoring of inflammation and tumors or cancer. Additional uses include the monitoring of test agents in assays to screen for COX-2 specific inhibitors and other laboratory uses.

  本发明提供了用于区分COX-1和COX-2活性的方法、组合物和试剂盒。特别地，本发明提供了在受试者、其样品以及实验室测试中检测和/或测量COX-2活性的方法。本发明揭示了2-花生四烯酸甘油酯是一种COX-2选择性底物，可被COX-2代谢成前列腺素甘油酯（PG-Gs），而PG-Gs的多样性与COX源自花生四烯酸的代谢产物相似。本发明还提供了某些新的COX-2选择性代谢产物，包括前列腺素I2-甘油酯（PGI2-G）和6-酮前列腺素F1α-甘油酯。描述了用于检测COX-2活性的方法和试剂盒，包括检测PG-Gs（包括本文所披露的新PG-Gs）。这些方法和试剂盒的用途包括检测和监测炎症、肿瘤或癌症。另外的用途包括监测试剂在筛选COX-2特异性抑制剂和其他实验室用途中的作用。
• Pyrazolo(1,5-a)pyridine derivatives and compositions containing them
  申请人：KYORIN PHARMACEUTICAL CO., LTD.

  公开号：EP0121806A1

  公开（公告）日：1984-10-17

  The present invention concerns the pyrazolo-[1,5-a]-pyridine derivatives which are antiallergic agents, referred to as SRS-A release inhibitors, and useful for treatment of allergic diseases.

  本发明涉及吡唑-[1,5-a]-吡啶衍生物，它们是抗过敏剂，被称为 SRS-A 释放抑制剂，可用于治疗过敏性疾病。
• Coumaran derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0273647A1

  公开（公告）日：1988-07-06

  A compound of the formula wherein R is a lower alkyl group, R0 is hydrogen or an acyl group, R1 and R2 are lower alkyl groups which may optionally be substituted or wherein R1 and R2 are combined to form a butadienylene group which may optionally be substituted, R3 and R4 are hydrogen or alkyl groups which may 'optionally be substituted or wherein R3 and R4 are combined to form a polymethylene group, and R5 is a lower alkyl, aromatic or heterocyclic group which may optionally be substituted or a pharmaceutically acceptable salt thereof, exerts cardiovascular system improving action and antiallergic action and can be used as pharmaceutics, e.g. antithromotics, antiallergic agents etc.

  式中 R 为低级烷基，R0 为氢或酰基，R1 和 R2 为可选择被取代的低级烷基，或其中 R1 和 R2 结合形成可选择被取代的丁二烯基，R3 和 R4 为氢或可'选择被取代的烷基，或其中 R3 和 R4 结合形成聚亚甲基，R5 为可选择被取代的低级烷基、芳香族或杂环基，或其药学上可接受的盐的化合物，具有改善心血管系统和抗过敏作用，可用作药物，如抗肿瘤药、抗过敏药等。
• Thiazolo[5,4-b]azepine compounds
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0351856A2

  公开（公告）日：1990-01-24

  New thiazolo [5,4-b]azepine compounds represented by ,wherein R¹ is a hydrogen atom, an aliphatic group which may be substituted, a carboxylic acyl group which may be substituted or a sulfonic acyl group which may be substituted; R² is a hydrogen atom, an aromatic group which may be substituted or an aliphatic group which may be substituted, which are capable of e.g., inhibiting lipoperoxide formation.

  新的噻唑并[5,4-b]氮杂卓化合物，其代表如下 其中 R¹ 是氢原子、可被取代的脂肪族基团、可被取代的羧酸酰基或可被取代的磺酸酰基；R² 是氢原子、可被取代的芳香族基团或可被取代的脂肪族基团。
• Chalcone plant extracts for use in therapy
  申请人：THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON

  公开号：EP0998939A1

  公开（公告）日：2000-05-10

  An extract of Glycyrrhiza usually G.glabra and specific chalcones contained therein, have useful therapeutic properties for the treatment ofpsoriasis. The most active compounds are identified as licochalcone B and echinatin, both of which are more active than isoliquiritigenin, which has adequate performance. The compounds and/or extract are expected to be administered topically to skin affected by psoriasis.

  甘草提取物及其中所含的特定查耳酮具有治疗牛皮癣的功效。经鉴定，最有效的化合物是甘草查耳酮 B 和棘白甙，这两种化合物的活性都高于具有适当疗效的异桔梗甙元。预计这些化合物和/或提取物可局部用于银屑病患者的皮肤。