5-氯-2-甲基异噻唑啉-3-酮盐酸盐 | 26530-03-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 中文名称: 5-氯-2-甲基异噻唑啉-3-酮盐酸盐
• 中文别名: 5-氯-2-甲基-3(2H)-异噻唑酮盐酸盐
• 英文名称: 5-chloro-2-methyl-isothiazol-3-one; hydrochloride
• 英文别名: 5-chloro-2-methyl-2H-isothiazol-3-one hydrochloride；5-chloro-2-methyl-3-isothiazolone hydrochloride salt；5-chloro-2-methyl-4-isothiazolin-3-one hydrochloride；5-Chloro-2-methyl-3-isothiazolone; hydron; chloride；5-chloro-2-methyl-1,2-thiazol-3-one;hydron;chloride
• CAS: 26530-03-0
• 化学式: C₄H₄ClNOS*ClH
• 分子量: 186.062
• InChiKey: RGVYUPIYFIVQDS-UHFFFAOYSA-N

物化性质

• 溶解度：
  乙醇：微溶

计算性质

• 辛醇/水分配系数(LogP)：
  1.52
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  45.6
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  5-氯-2-甲基异噻唑啉-3-酮盐酸盐 在 氯 作用下， 以 乙酸乙酯 为溶剂， 生成 4,4,5,5-四氯-2-甲基-1,2-噻唑烷-3-酮
  参考文献：
  名称：

  Weiler,E.D. et al., Journal of Heterocyclic Chemistry, 1976, vol. 13, p. 1321 - 1323

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基异噻唑啉酮 、 5-氯-2-甲基-4-异噻唑啉-3-酮 、 4,5-二氯-2-甲基-3(2H)-异噻唑啉酮 生成 5-氯-2-甲基异噻唑啉-3-酮盐酸盐
  参考文献：
  名称：

  LINDNER, WOLFGANG

  摘要：

  DOI：

文献信息

• Isothiazolidin-3-ones
  申请人：Rohm and Haas Company

  公开号：US04169949A1

  公开（公告）日：1979-10-02

  Isothiazolidin-3-ones of the formula ##STR1## wherein R.sup.1 is a hydrogen atom, or an alkyl, cycloalkyl, aryl, aralkyl, carbamoyl, or thiocarbamoyl group, R.sup.2 and R.sup.3 are halogen atoms or alkyl groups, and X is a halogen atom and compositions containing them are useful in controlling microorganisms, such as bacteria, fungi, algae, and the like.

  式为##STR1##的异噻唑啉-3-酮，其中R.sup.1是氢原子，或者是烷基、环烷基、芳基、芳基烷基、氨基甲酰基或硫氨基甲酰基基团，R.sup.2和R.sup.3是卤素原子或烷基基团，X是卤素原子，含有它们的组合物在控制微生物（如细菌、真菌、藻类等）方面是有用的。
• Pyranopyranone derivatives as antimicrobial agents
  申请人：Wagner Barbara

  公开号：US20110224170A1

  公开（公告）日：2011-09-15

  Disclosed is the use of pyranopyranone derivatives of formula wherein R 1 , R 2 , R 3 , R 4 and R 5 independently of one another are hydrogen; C 1 -C 30 alkyl, C 2 -C 30 alkenyl, or C 3 -C 12 cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C 6 -C 20 aryl, which may be substituted by one or more G; C 4 -C 20 heteroaryl, which may be substituted by one or more G, C 2 -C 18 alkenyl, C 2 -C 18 alkynyl, C 7 -C 25 aralkyl, or —CO—R 6 ; —SiR 8 R 9 R 10 ; or R 4 and R 5 together form a five or six membered ring; or R 3 and R 4 together form a five or six membered ring; D is —CO—; —COO—; —S—; —SO—; —SO 2 —; —O—; —NR 7 —; —SiR 8 R 9 —; —POR 10 —; —CR 12 ═CR 13 —; or —C≡C—; and E is —OR 6 ; —SR 6 ; —NR 14 R 15 ; —NR 14 COR 15 ; —COR 6 ; —COOR 6 ; —CONR 14 R 15 ; —CN; halogen; or OSO 3 R 11 ; SO 3 R 11 ; SO 2 R 11 ; PO 3 (R 11 ) 2 ; OPO 3 (R 11 ) 2 ; G is E; C 1 -C 18 alkyl, which is optionally interrupted by D; C 1 -C 18 perfluoroalkyl; C 1 -C 18 alkoxy, which is optionally substituted by E and/or interrupted by D; wherein R 6 is H; C 6 -C 18 aryl which is optionally substituted by OH, C 1 -C 30 alkyl or C 1 -C 30 alkoxy; or C 1 -C 30 alkyl which is optionally interrupted by —O—; R 7 is H; C 6 -C 18 aryl which is optionally substituted by OH, C 1 -C 30 alkyl or C 1 -C 30 alkoxy; or C 1 -C 30 alkyl which is optionally interrupted by —O—; R 8 , R 9 and R 10 independently of each other are hydrogen; C 1 -C 30 alkyl; C 6 -C 18 aryl which is optionally substituted by C 1 -C 30 alkyl; and R 11 is hydrogen; C 6 -C 18 aryl, which is optionally substituted by OH, C 1 -C 30 alkyl or C 1 -C 30 alkoxy; or C 1 -C 30 alkyl, which is optionally interrupted by —O—; R 12 , R 13 , R 14 and R 15 independently of each other are hydrogen; C 6 -C 18 aryl which is optionally substituted by OH, C 1 -C 30 alkyl or C 1 -C 30 alkoxy; C 1 -C 30 alkyl, which is optionally interrupted by —O—; or R 14 and R 15 together form a five or six membered ring; as antimicrobial and/or preserving agents.

  本发明涉及使用式（I）的吡喃并吡喃酮衍生物，其中R1、R2、R3、R4和R5独立地为氢；C1-C30烷基，C2-C30烯基或C3-C12环烷基，可以被一个或多个E取代和/或被一个或多个D打断；C6-C20芳基，可以被一个或多个G取代；C4-C20杂环芳基，可以被一个或多个G取代，C2-C18烯基，C2-C18炔基，C7-C25芳基烷基或-CO-R6；-SiR8R9R10；或R4和R5一起形成五元或六元环；或R3和R4一起形成五元或六元环；D是-CO-；-COO-；-S-；-SO-；-SO2-；-O-；-NR7-；-SiR8R9-；-POR10-；-CR12═CR13-；或-C≡C-；E是-OR6；-SR6；-NR14R15；-NR14COR15；-COR6；-COOR6；-CONR14R15；-CN；卤素；或OSO3R11；SO3R11；SO2R11；PO3（R11）2；OPO3（R11）2；G是E；C1-C18烷基，可选地被D打断；C1-C18全氟烷基；C1-C18烷氧基，可选地被E取代和/或被D打断；其中R6是H；C6-C18芳基，可选地被OH，C1-C30烷基或C1-C30烷氧基取代；或C1-C30烷基，可选地被-O-打断；R7是H；C6-C18芳基，可选地被OH，C1-C30烷基或C1-C30烷氧基取代；或C1-C30烷基，可选地被-O-打断；R8、R9和R10独立地为氢；C1-C30烷基；C6-C18芳基，可选地被C1-C30烷基取代；R11为氢；C6-C18芳基，可选地被OH，C1-C30烷基或C1-C30烷氧基取代；或C1-C30烷基，可选地被-O-打断；R12、R13、R14和R15独立地为氢；C6-C18芳基，可选地被OH，C1-C30烷基或C1-C30烷氧基取代；C1-C30烷基，可选地被-O-打断；或R14和R15一起形成五元或六元环；作为抗微生物和/或保藏剂。
• Methods and Compositions for Use in Glued-Wood Products
  申请人：Lonza Solutions AG

  公开号：US20210400975A1

  公开（公告）日：2021-12-30

  The present invention relates to biocide-composites providing high retention of biocides in glueline-treated glued-wood products that are hot-pressed or hot-pressed and block-stacked during manufacture.

  本发明涉及生物杀菌剂复合物，该复合物在制造过程中热压或热压并堆垛的胶合木制品中提供高保留生物杀菌剂的能力。
• Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
  申请人：McDaniel C. Steven

  公开号：US20100210745A1

  公开（公告）日：2010-08-19

  Disclosed herein are polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a textile finish or a wax; a filler for such a polymeric material or a surface treatment that includes an enzyme such as an esterase (e.g., a lipolytic enzyme, a sulfuric ester hydrolase, an organophosphorus compound degradation enzyme), an enzyme (e.g., a lysozyme, a lytic transglycosylase) that degrades a cell wall and/or a cell membrane component, a biocidal or biostatic peotide, and/or a peptidase. Also disclosed herein are methods of altering a material's property such as service life, flexability, or rigidity, by incorporation of an enzyme into a material capable of being chemically crosslinked by the activity of a lipolytic enzyme, a hydrolase, and/or a urease.

  本文公开了一些聚合材料，如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；一种表面处理，如纺织品涂层或蜡；一种填料，用于这样的聚合材料或表面处理，其中包括一种酶，如酯酶（例如，脂肪水解酶，硫酸酯水解酶，有机磷化合物降解酶），降解细胞壁和/或细胞膜成分的酶（例如，溶菌酶，裂解转糖基酶），生物杀菌或生物静态肽，以及/或肽酶。本文还公开了通过将酶纳入可通过脂肪水解酶、水解酶和/或脲酶的活性交联材料中来改变材料性能，如使用寿命、柔韧性或刚度的方法。
• Polymeric Coatings Incorporating Bioactive Enzymes for Catalytic Function
  申请人：McDaniel C. Steven

  公开号：US20120097194A1

  公开（公告）日：2012-04-26

  Disclosed herein are materials including a polymeric materials such as a coating, a plastic, a laminate, a composite, an elastomer, an adhesive, or a sealant; a surface treatment such as a coating, a textile finish or a wax; a filler for such a polymeric material or a surface treatment, which includes an enzyme such as an esterase (e.g., a lipolytic enzyme, an organophosphorus compound degradation enzyme), wherein the enzyme decontaminates a chemical from the surface of the material. Also disclosed herein are methods of cleaning a surface of a material that comprises an enzyme.

  本文公开了一种材料，包括聚合物材料，例如涂层、塑料、层压板、复合材料、弹性体、粘合剂或密封剂；表面处理，例如涂层、纺织品处理或蜡；用于上述聚合物材料或表面处理的填料，其中包括酶，例如酯酶（例如脂肪水解酶、有机磷化合物降解酶），其中酶可从材料表面去除化学物质。本文还公开了一种清洁含有酶的材料表面的方法。