N-methyl-N-phenyl-3-cyano-4,6-dimethylpyridine-2-sulfonylamide | 899373-25-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-methyl-N-phenyl-3-cyano-4,6-dimethylpyridine-2-sulfonylamide
• 英文别名: 3-cyano-N,4,6-trimethyl-N-phenylpyridine-2-sulfonamide
• CAS: 899373-25-2
• 化学式: C₁₅H₁₅N₃O₂S
• 分子量: 301.369
• InChiKey: YEEQADNRUPIOGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  82.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-cyano-4,6-dimethylpyridine-2-sulfonyl chloride 、 N-甲基苯胺 在 三乙胺 作用下， 以 水 、 丙酮 为溶剂， 以64%的产率得到N-methyl-N-phenyl-3-cyano-4,6-dimethylpyridine-2-sulfonylamide
  参考文献：
  名称：

  3-Cyano-4,6-dimethyl-5-R-pyridine-2-sulfonyl chlorides and N-substituted sulfonylamides based on them

  摘要：

  3-Cyanopyridine-2-sulfonyl chlorides were synthesized by the oxidative chlorination of the respective 3-cyanopyridine-2(1H)-2-thiones. It was established that 3-cyano-4,6-dimethylpyridine-2-sulfonyl chloride eliminates a SO(2) molecule at the isolation stage. N-Substituted sulfonylamides based on the latter were obtained by the reaction of the crude sulfonyl chloride with amines in an aqueous medium.

  DOI：

  10.1007/s10593-009-0386-4

文献信息

• 3-Cyano-4,6-dimethyl-5-R-pyridine-2-sulfonyl chlorides and N-substituted sulfonylamides based on them
  作者：I. G. Dmitrieva、L. V. Dyadyuchenko、V. D. Strelkov、E. A. Kaigorodova

  DOI：10.1007/s10593-009-0386-4

  日期：2009.9

  3-Cyanopyridine-2-sulfonyl chlorides were synthesized by the oxidative chlorination of the respective 3-cyanopyridine-2(1H)-2-thiones. It was established that 3-cyano-4,6-dimethylpyridine-2-sulfonyl chloride eliminates a SO(2) molecule at the isolation stage. N-Substituted sulfonylamides based on the latter were obtained by the reaction of the crude sulfonyl chloride with amines in an aqueous medium.