2,3-Dinor-TXB2 | 63250-09-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,3-Dinor-TXB2
• 英文别名: (Z)-5-[(2R,3S,4S)-4,6-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]oxan-3-yl]pent-3-enoic acid
• CAS: 63250-09-9
• 化学式: C₁₈H₃₀O₆
• 分子量: 342.4
• InChiKey: RJHNVFKNIJQTQF-LMIBIYGPSA-N

物化性质

• 溶解度：
  DMF：>50 mg/ml（来自 TXB2）； DMSO：>25 mg/ml（来自 TXB2）；乙醇：>100 mg/ml（来自 TXB2）； PBS pH 7.2：>100 mg/ml（来自 TXB2）
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Compositions for enzyme immunoassay of prostaglandins
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0166583A2

  公开（公告）日：1986-01-02

  The present invention relates to compositions for enzyme immunoassay of prostaglandins (e.g. prostaglandins, throm- boxanes and leukotrienes) which comprises at least the following reagents: Reagent (A) (the first antibody obtained by immunizing the conjugate of prostaglandins with a protein to the first animal), Reagent (B) (the antigen consisting of enzyme-labelled prostaglandins) and Reagent (C) (the adsorbent of the second antibody obtained by immunizing y-globulin or immunoglobulin G of the first animal to the second animal, to support). By using compositions of the present invention, trace amounts of prostaglandins in sample can be measured by more simplified procedure, and the measurement is surprisingly excellent in the range and limitation of detection, and assay precision.

  本发明涉及用于前列腺素（如前列腺素、血栓素和白三烯）酶免疫测定的组合物，该组合物至少包括以下试剂：试剂（A）（第一种动物免疫前列腺素与蛋白质的共轭物而获得的第一抗体）、试剂（B）（由酶标记的前列腺素组成的抗原）和试剂（C）（第二种动物免疫第一种动物的 y 球蛋白或免疫球蛋白 G 而获得的第二抗体的吸附剂，以支持）。 使用本发明的组合物，可以通过更简便的程序测量样品中的痕量前列腺素，而且在检测范围和限制以及检测精度方面，测量效果出奇地好。
• Determination of arachidonic acid derivatives and kits therefore
  申请人：Sankyo Company Limited

  公开号：EP0336647A2

  公开（公告）日：1989-10-11

  A method is provided for the determination of an analyte in a sample, wherein the analyte is an arachidonic acid derivative selected from prostaglandins, thromboxanes and leukotrienes. The method combines a simple and effective clean-up pretreatment based on affinity chromatography, with an enzyme immunoassay.

  提供了一种测定样品中分析物的方法，其中分析物为花生四烯酸衍生物，选自前列腺素、血栓素和白三烯。该方法将基于亲和层析的简单有效的净化预处理与酶免疫测定相结合。
• Controlled-release, low-dose aspirin
  申请人：STERLING WINTHROP INC.

  公开号：EP0377439A2

  公开（公告）日：1990-07-11

  An aqueous-based formulation for coating aspirin granules to provide granules that may be compressed into tablets and that show approximately zero-order release kinetics for release rates of 5 to 15 mg/hour over a period extending five to eight hours is provided. The coating formulation preferably consists of an acrylate/methacrylate copolymer, hydroxypropylmethylcellulose, sodium chloride and talc. A film-coated tablet comprised of the coated granules, filler granules, excipients, binders and disintegrants is also provided, as are processes for preparing the tablets and granules and methods for their use in the treatment of vascular occlusive diseases.

  本发明提供了一种水基配方，用于包衣阿司匹林颗粒，以提供可压制成片剂的颗粒，并在 5 至 8 小时的释放时间内，以 5 至 15 毫克/小时的释放速率显示近似零阶释放动力学。包衣配方最好由丙烯酸酯/甲基丙烯酸酯共聚物、羟丙基甲基纤维素、氯化钠和滑石粉组成。还提供了由包衣颗粒、填充颗粒、赋形剂、粘合剂和崩解剂组成的薄膜包衣片剂，以及制备片剂和颗粒的工艺及其用于治疗血管闭塞性疾病的方法。
• SUPPRESSION OF THROMBOXANE LEVELS BY PERCUTANEOUS ADMINISTRATION OF ASPIRIN
  申请人：GUNDERSON MEDICAL FOUNDATION, LTD.

  公开号：EP0578780A1

  公开（公告）日：1994-01-19
• NEW USE OF OMEGA-3-FATTY ACIDS
  申请人：Fresenius Kabi AB

  公开号：EP0627918B1

  公开（公告）日：2001-10-31