2-Amino-muconic acid | 4548-99-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-muconic acid
• 英文别名: (2E,4Z)-2-aminohexa-2,4-dienedioic acid
• CAS: 4548-99-6
• 化学式: C₆H₇NO₄
• 分子量: 157.12
• InChiKey: ZRHONLCTYUYMIQ-HSFFGMMNSA-N

物化性质

• 沸点：
  368.4±32.0 °C(Predicted)
• 密度：
  1.461±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2922499990

文献信息

• Directed evolution of recombinant monooxygenase nucleic acids and related polypeptides and methods of use
  申请人：Wood K. Thomas

  公开号：US20060051782A1

  公开（公告）日：2006-03-09

  The present invention relates to novel monooxygenase nucleic acids and polypeptides created using mutagenesis, DNA shuffling, or both, in a single iteration or multiple iterations, and methods for their creation and use. The monooxygenase enzymes of the present disclosure have particular utility as biocatalysts in industrial chemical redox reactions, such as the oxidation of aromatic hydrocarbons, for example, toluene, benzene, or nitrobenzene, into industrially desirable products. The systems and processes of the present invention are especially useful for the coupled synthesis and recovery of catechols, methylcatechols, resorcinols, methylresorcinols, hydroquinones, methylhydroquinones, hydroxybenzenes, cresols, nitrobenzenes, and nitrohydroxyquinones.

  本发明涉及使用突变、DNA重组或两者结合的方法，在单次迭代或多次迭代中创建的新型单加氧酶核酸和多肽，以及它们的创建和使用方法。本公开的单加氧酶酶在工业化学氧化还原反应中具有特定的生物催化剂实用性，例如将芳香族烃类（例如甲苯、苯或硝基苯）氧化成工业上所需的产品。本发明的系统和过程特别适用于咖啡酚、甲基咖啡酚、间苯二酚、甲基间苯二酚、对苯二酚、甲基对苯二酚、羟基苯、甲酚、硝基苯和硝基羟基苯的耦合合成和回收。
• Tandem repeat DNA constructs producing proteins that attack plant pathogenic viruses, fungi, and bacteria by disrupting transcription factors essential for replication thereof in plants
  申请人：Fernandez-Pol, Sebastian

  公开号：EP2123762A2

  公开（公告）日：2009-11-25

  Methods and compositions related to treating, controlling or inhibiting Geminiviruses by reducing or inhibiting growth of Geminiviruses (GV) employing a compound having the following structure: or a pharmaceutically acceptable salt thereof, wherein R1 R2, R3 and R4 are selected from a group consisting of a carboxyl group, methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, secondary butyl group, tertiary butyl group, pentyl group, isopentyl group, neopentyl group, fluorine, chlorine, bromine, iodine, and hydrogen. The present invention provides several classes of antiviral compounds which can be used to inactivate or disintegrate geminiviruses, such as the African cassava mosaic geminiviruses (ACMV) and East Africa cassava mosaic geminiviruses (EACMGV), by attacking the [ Zn 2+]-[CCHC] zinc finger domain or a variation thereof, such domain being present in the viral nucleocapsid or other viral ZFPs. The novel antiviral agents were designed to be used in plants infected by pathogenic viruses.

  通过使用具有以下结构的化合物来减少或抑制革兰氏病毒（GV）的生长，从而治疗、控制或抑制革兰氏病毒的方法和组合物： 或其药学上可接受的盐，其中 R1 R2、R3 和 R4 选自由羧基、甲基、乙基、丙基、异丙基、丁基、异丁基、仲丁基、叔丁基、戊基、异戊基、新戊基、氟、氯、溴、碘和氢组成的组。本发明提供了几类抗病毒化合物，它们可以通过攻击[Zn 2+]-[CCHC] 锌指结构域或其变体（这种结构域存在于病毒核壳或其他病毒 ZFP 中）来灭活或分解 geminiviruses，如非洲木薯花叶病毒（ACMV）和东非木薯花叶病毒（EACMGV）。新型抗病毒制剂设计用于受病原病毒感染的植物。
• THE USE OF ZEBURALINE FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR IMMUNE REJECTION OF TRANSPLANTS
  申请人：Idogen AB

  公开号：EP2164500B1

  公开（公告）日：2013-12-04
• Method and Device for Thermal Conditioning of a Cell
  申请人：Dauner Michael

  公开号：US20070298484A1

  公开（公告）日：2007-12-27

  The invention relates to methods and agents for thermal conditioning of a biological cell, methods and uses of said agents for releasing and insulating ingredients outside the biological cell, and for quantitatively and qualitatively detecting the released ingredient and to a method for sampling biological cells which consists in carrying out in one step the sampling said biological cells in a culture medium and in releasing cellular ingredients during said sampling. Sampling devices are also disclosed.
• US6432683B1
  申请人：——

  公开号：US6432683B1

  公开（公告）日：2002-08-13