11-deoxyprostaglandin F2α | 36969-91-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11-deoxyprostaglandin F2α
• 英文别名: 11-Deoxyprostaglandin F2a；11-deoxy-11-methylene PGD2；9S,15S-dihydroxy-5Z,13E-prostadienoic acid；(Z)-7-[(1R,2S,5R)-2-hydroxy-5-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
• CAS: 36969-91-2
• 化学式: C₂₀H₃₄O₄
• 分子量: 338.488
• InChiKey: YRFLKMLJQWGIIZ-APRRXLQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• US4130721A
  申请人：——

  公开号：US4130721A

  公开（公告）日：1978-12-19
• [EN] POLYMER CONJUGATED PROSTAGLANDIN ANALOGUES<br/>[FR] ANALOGUES DE PROSTAGLANDINE CONJUGUÉS À UN POLYMÈRE
  申请人：POLYACTIVA PTY LTD

  公开号：WO2012139164A1

  公开（公告）日：2012-10-18

  The present invention relates in general to polymer-drug conjugates. In particular, the invention relates to polymer-drug conjugates wherein the conjugated drugs are selected from prostaglandins and substituted prostaglandins, to a method of delivering such prostaglandin drugs to a subject, to a sustained drug delivery system comprising the polymer-drug conjugates, to a method of preparing the polymer-drug conjugates, and to an implant comprising the polymer-drug conjugates. The polymer-drug conjugates may be useful for delivering prostaglandins and substituted prostaglandins for the treatment of glaucoma.