2-(bromophenyl-2-thioyl)tetrahydro-2H-pyran | 620988-02-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-(bromophenyl-2-thioyl)tetrahydro-2H-pyran
• 英文别名: 2-(2-Bromophenyl)sulfanyloxane
• CAS: 620988-02-5
• 化学式: C₁₁H₁₃BrOS
• 分子量: 273.194
• InChiKey: CJKQBEJRBDPCLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(bromophenyl-2-thioyl)tetrahydro-2H-pyran 在 sodium tetrasulfide 、 仲丁基锂 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 6.33h， 生成
  参考文献：
  名称：

  Development of a reversible fluorescent probe for reactive sulfur species, sulfane sulfur, and its biological application

  摘要：

  我们开发了一种可逆荧光探针，用于检测硫醚硫的浓度变化。

  DOI：

  10.1039/c6cc08372b
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 2-溴硫代苯酚 在 三氟化硼乙醚 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以80%的产率得到2-(bromophenyl-2-thioyl)tetrahydro-2H-pyran
  参考文献：
  名称：

  Development of a reversible fluorescent probe for reactive sulfur species, sulfane sulfur, and its biological application

  摘要：

  我们开发了一种可逆荧光探针，用于检测硫醚硫的浓度变化。

  DOI：

  10.1039/c6cc08372b

文献信息

• Fluoro oxindole derivatives as modulators of KCNQ potassium channels
  申请人：——

  公开号：US20020156120A1

  公开（公告）日：2002-10-24

  There is provided novel 3-fluoro-3-phenyl oxindole derivatives of Formula I 1 wherein R 1 , R 2 , R 3 and R 4 each are independently hydrogen, C 1-4 alkyl, halogen, fluoromethyl, trifluoromethyl, phenyl, 4-methylphenyl or 4-trifluoromethylphenyl; R 5 is C 1-6 alkyl optionally substituted with one to three same or different groups selected from fluoro and chloro, provided R 5 is not C 1-6 alkyl when Y is O; Y is O or S; and R 6 and R 7 each are independently hydrogen, chloro, bromo or trifluoromethy; which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.

  提供了一种新的式I1的3-氟-3-苯基吲哚衍生物，其中R1、R2、R3和R4各自独立地为氢、C1-4烷基、卤素、氟甲基、三氟甲基、苯基、4-甲基苯基或4-三氟甲基苯基；R5为C1-6烷基，可选地取代一到三个相同或不同的氟或氯基，但当Y为O时，R5不为C1-6烷基；Y为O或S；R6和R7各自独立地为氢、氯、溴或三氟甲基；它们是KCNQ钾通道的开放剂，可用于治疗对KCNQ钾通道开放有反应的疾病。
• Fused λ5-Phosphinines: Design, Syntheses, and Properties
  作者：Minoru Hayashi、Hidetoshi Ohta、Shion Fujimoto

  DOI：10.1055/a-1979-6123

  日期：——

  λ5-phosphinines through intramolecular cyclization is described. The incorporation of a heteroatom affected their photophysical properties through perturbation of the LUMO level, which is in good contrast to the HOMO-based tuning by the C-4 substituent. The C-3-substituent-based property tuning provides a new guide to designing phosphinine-based fluorophores.

  描述了通过分子内环化合成几种杂环融合的 λ 5 -膦。杂原子的掺入通过扰动 LUMO 能级影响了它们的光物理性质，这与 C-4 取代基基于 HOMO 的调谐形成了鲜明的对比。基于 C-3 取代基的性质调整为设计基于膦的荧光团提供了新的指导。
• FLUORO OXINDOLE DERIVATIVES AS MODULATORS OF KCNQ POTASSIUM CHANNELS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1363624A2

  公开（公告）日：2003-11-26
• BRIDGED BI-AROMATIC LIGANDS, COMPLEXES, CATALYSTS, PROCESSES FOR POLYMERIZING AND POLYMERS THEREFROM
  申请人：Symyx Solutions, Inc.

  公开号：EP1501840B1

  公开（公告）日：2010-12-22
• Bridged Bi-Aromatic Ligands, Catalysts, Processes For Polymerizing And Polymers Therefrom
  申请人：Boussie Thomas R.

  公开号：US20080269470A1

  公开（公告）日：2008-10-30

  New ligands and compositions with bridged bis-aromatic ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene.