(2R)-2-ethyl-2-hydroxybutanedioic acid | 873073-25-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R)-2-ethyl-2-hydroxybutanedioic acid
• CAS: 873073-25-7
• 化学式: C₆H₁₀O₅
• 分子量: 162.14
• InChiKey: YVYGHRNLPUMVBU-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Engineered CO2 fixing microorganisms producing carbon-based products of interest
  申请人：Joule Unlimited Technologies, Inc.

  公开号：EP2706111A1

  公开（公告）日：2014-03-12

  The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.

  本公开确定了在光自养生物体中生产乙醇、乙烯、化学品、聚合物、正烷烃、异戊烯、医药产品或其中间体等相关碳基产品的途径和机制，从而使这些生物体有效地将二氧化碳和光转化为相关碳基产品，特别是利用这些生物体进行乙醇、乙烯、化学品、聚合物、正烷烃、异戊烯、医药产品或其中间体的商业化生产。
• Biological production of multi-carbon compounds from methane
  申请人：INTREXON CORPORATION

  公开号：US10876137B2

  公开（公告）日：2020-12-29

  Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications. The present invention provides metabolically engineered host microorganisms which metabolize methane (CH4) as their sole carbon source to produce multi-carbon compounds for use in fuels (e.g., bio-fuel, bio-diesel) and bio-based chemicals. Furthermore, use of the metabolically engineered host microorganisms of the invention (which utilize methane as the sole carbon source) mitigate current industry practices and methods of producing multi-carbon compounds from petroleum or petroleum-derived feedstocks, and ameliorate much of the ongoing depletion of arable food source “farmland” currently being diverted to grow bio-fuel feedstocks, and as such, improve the environmental footprint of future bio-fuel, bio-diesel and bio-based chemical compositions.

  乙醇、正丁醇、仲丁醇、异丁醇、叔丁醇、脂肪（或脂肪族长链）醇、脂肪酸甲酯、2,3-丁二醇等多碳化合物是重要的工业商品化学品，具有多种用途。本发明提供了代谢工程宿主微生物，它们将甲烷（CH4）作为唯一碳源进行代谢，生产出多碳化合物，用于燃料（如生物燃料、生物柴油）和生物基化学品。此外，使用本发明的代谢工程宿主微生物（利用甲烷作为唯一碳源）可减轻目前利用石油或石油衍生原料生产多碳化合物的行业实践和方法，并改善目前为种植生物燃料原料而占用的大量可耕地，从而改善未来生物燃料、生物柴油和生物基化学品组合物的环境足迹。
• ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST
  申请人：Joule Unlimited, Inc.

  公开号：EP2285948A1

  公开（公告）日：2011-02-23
• ETHANOL PRODUCTION BY MICROORGANISMS
  申请人：Joule Unlimited, Inc.

  公开号：EP2344652A1

  公开（公告）日：2011-07-20
• Engineered CO2 Fixing Microorganisms Producing Carbon-Based Products of Interest
  申请人：Berry David A.

  公开号：US20110008861A1

  公开（公告）日：2011-01-13

  The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.