2-Trichloracetamid-5-nitro-benzophenon | 26313-35-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Trichloracetamid-5-nitro-benzophenon
• 英文别名: 2-Trichloracetamido-5-nitro-benzophenon；5-nitro-2-(2,2,2-trichloro-acetylamino)-benzophenone；2-Trichloroacetamido-5-nitrobenzophenone；N-(2-benzoyl-4-nitrophenyl)-2,2,2-trichloroacetamide
• CAS: 26313-35-9
• 化学式: C₁₅H₉Cl₃N₂O₄
• 分子量: 387.606
• InChiKey: XHKHRIWVSSVZIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  92
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Trichloracetamid-5-nitro-benzophenon 生成 6-nitro-4-phenyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
  参考文献：
  名称：

  1,4-二氢-2H-3,1-苯并恶嗪-2-酮衍生物的合成及药理评价。

  摘要：

  DOI：

  10.1002/jps.2600601147
• 作为产物：
  描述：

  三氯乙酰氯 、 2-氨基-5-硝基二苯甲酮 生成 2-Trichloracetamid-5-nitro-benzophenon
  参考文献：
  名称：

  BOGATSKIJ A. V.; ANDRONATI S. A.; ZHILINA Z. I.; DANILINA N. I., ZH. ORGAN. XIMII, 1977, 13, HO 8,

  摘要：

  DOI：

文献信息

• Fused quinazolinones and a process for production thereof
  申请人：Sumitomo Chemical Company, Limited

  公开号：US03980645A1

  公开（公告）日：1976-09-14

  Fused quinazolinone derivatives of the formula, ##SPC1## Wherein R.sub.1 and R.sub.2 are individually hydrogen, C.sub.1.sub.-4 alkyl, C.sub.1.sub.-4 alkoxy, nitro, C.sub.1.sub.-4 alkylsulfonyl or halogen; R.sub.3 is pyridyl, thienyl or a group of the formula ##SPC2## Wherein R.sub. 4 is hydrogen or halogen; R is hydrogen, C.sub.1.sub.-4 alkyl, C.sub.2.sub.-5 alkenyl, aralkyl, (C.sub.3.sub.-6 cycloalkyl)C.sub.1.sub.-4 alkyl, (C.sub.1.sub.-4 alkoxy)C.sub.1.sub.-4 alkyl, (C.sub.1.sub.-4 alkylthio)C.sub.1.sub.-4 alkyl, hydroxy-C.sub.1.sub.-4 alkyl or C.sub.2.sub.-5 alkanoyloxy-C.sub.1.sub.-4 alkyl; Y is oxygen, or a group of the formula N - R.sub.5, wherein R.sub.5 is hydrogen or C.sub.1.sub.-4 alkyl; and Z is C.sub.2.sub.-5 alkylene or alkenylene, are prepared by reacting a trihaloacetamidophenyl ketone derivative of the formula, ##SPC3## Wherein R.sub.1, R.sub.2, R.sub. 3 and R are as defined above; and X.sub.1, X.sub.2 and X.sub.3 are halogen, with an amine of the formula, HY - Z - NH.sub.2, wherein Y and Z are as defined above, or a salt thereof, in the presence of a solvent or a mixture thereof. They have remarkable pharmacological properties such as anti-inflammatory, analgesic and/or uricosuric activities.

  化合物的熔合喹唑啉衍生物的公式为：##SPC1## 其中，R1和R2分别为氢、C1-4烷基、C1-4烷氧基、硝基、C1-4烷基磺酰基或卤素；R3为吡啶基、噻吩基或公式##SPC2##的基团，其中R4为氢或卤素；R为氢、C1-4烷基、C2-5烯丙基、苯基甲基、(C3-6环烷基)C1-4烷基、(C1-4烷氧基)C1-4烷基、(C1-4烷硫基)C1-4烷基、羟基-C1-4烷基或C2-5酰氧基-C1-4烷基；Y为氧或公式N-R5的基团，其中R5为氢或C1-4烷基；Z为C2-5烷基或烯基烷基。该化合物通过将公式##SPC3##中的三卤代酰胺苯酮衍生物与公式HY-Z-NH2的胺或其盐在溶剂或混合物中反应制备而成。它们具有显著的药理作用，如抗炎、镇痛和/或利尿作用。
• Quinazolinone derivatives possessing calcium uptake inhibiting activity
  申请人：Sumitomo Pharmaceuticals Co., Ltd.

  公开号：US05556860A1

  公开（公告）日：1996-09-17

  This invention is to provide quinazolinone derivatives, and their acid salts and quaternary ammonium salts, having an effect of preventing or treating diseases caused by calcium ion overload in cells, such as ischemic heart disease, ischemic cerebral disease and ischemic renal disease, and their usage. The quinazolinone derivatives are represented by the formula: ##STR1## typically, T represents an oxygen atom; Y represents a phenyl or cyclohexyl group; R.sup.1 represents a hydrogen or chlorine atom; R.sup.2 represents a hydrogen atom; ring W represents a benzene or pyridine ring; Z represents a group of the formula: ##STR2##

  本发明提供了喹唑啉酮衍生物及其酸盐和季铵盐，具有预防或治疗细胞内钙离子过载引起的疾病的作用，例如缺血性心脏病、缺血性脑病和缺血性肾病，以及它们的用途。喹唑啉酮衍生物由以下公式表示：##STR1## 通常，T代表氧原子；Y代表苯基或环己基；R.sup.1代表氢原子或氯原子；R.sup.2代表氢原子；环W代表苯环或吡啶环；Z代表以下公式的基团：##STR2##
• Quinazolinone derivatives
  申请人：SUMITOMO PHARMACEUTICALS COMPANY, LIMITED

  公开号：EP0626373A1

  公开（公告）日：1994-11-30

  This invention is to provide quinazolinone derivatives, and their acid salts and quaternary ammonium salts, having an effect of preventing or treating diseases caused by calcium ion overload in cells, such as ischemic heart disease, ischemic cerebral disease and ischemic renal disease, and their usage. The quinazolinone derivatives are represented by the formula: typically, T represents an oxygen atom; Y represents a phenyl or cyclohexyl group; R¹ represents a hydrogen or chlorine atom; R² represents a hydrogen atom; ring W represents a benzene or pyridine ring; Z represents a group of the formula:

  本发明旨在提供喹唑啉酮衍生物及其酸盐和季铵盐，具有预防或治疗细胞中钙离子超载引起的疾病，如缺血性心脏病、缺血性脑病和缺血性肾病的作用及其用途。喹唑啉酮衍生物由式表示： 通常，T 代表氧原子；Y 代表苯基或环己基；R¹ 代表氢原子或氯原子；R² 代表氢原子；环 W 代表苯环或吡啶环；Z 代表式中的基团：
• US3980645A
  申请人：——

  公开号：US3980645A

  公开（公告）日：1976-09-14
• US5556860A
  申请人：——

  公开号：US5556860A

  公开（公告）日：1996-09-17