[Cu(His)2] | 13870-80-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [Cu(His)2]
• 英文别名: Copper(2+) bis[2-amino-3-(1H-imidazol-5-yl)propanoate]；copper;2-amino-3-(1H-imidazol-5-yl)propanoate
• CAS: 13870-80-9
• 化学式: C₁₂H₁₆CuN₆O₄
• 分子量: 371.843
• InChiKey: UUYDYUZBCIHUFZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.94
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  190
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Multifunction "Crown Complexes" from Amino Acids and Peptides for Skin and Hair Restoration
  申请人：Gupta K Shyam

  公开号：US20070099886A1

  公开（公告）日：2007-05-03

  This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.

  本发明涉及从氨基酸和羟基芳基烷基酮衍生的席夫碱，或含有该类化合物的植物提取物，其具有图1中的一般化学结构，用于局部应用。本发明还涉及所述席夫碱的某些金属配合物，其在三维化学结构中呈冠状外观，如图2所示。本发明的席夫碱及其金属配合物对于调节金属活化酶和金属酶，例如苯丙氨酸羟化酶、酪氨酸转氨酶、苯丙氨酸转氨酶、酪氨酸酶、各种基质金属蛋白酶、超氧化物歧化酶、5α-还原酶和柠檬酸裂解酶具有用途。此外，它们还适用于多功能局部方法，如美白肌肤、减少皮肤皱纹、抗衰老、胶原蛋白合成、控制痤疮、预防脱发、控制白发和面部油脂控制。
• Hair Loss Prevention by Natural Amino Acid and Peptide Complexes
  申请人：GUPTA SHYAM K

  公开号：US20090253668A1

  公开（公告）日：2009-10-08

  This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related skin, hair and scalp problems, for example, hair aging including premature hair loss and hair graying; male pattern baldness; hair loss from dandruff; alopecia; split ends, acne, darkened skin, dark circles around eyes, stretch marks, wrinkles and fine lines, loss of collagen, loss of skin pliability and combinations thereof:

  本发明涉及公式（I）的某些皮肤和头发护理剂，这些护理剂源自天然氨基酸和肽。这些护理剂提供多功能的酶相关皮肤、头发和头皮问题的治疗，例如，头发老化，包括过早脱发和白发；男性型脱发；头皮屑引起的脱发；脱发斑秃；分叉，痤疮，皮肤变黑，眼周黑眼圈，妊娠纹，皱纹和细纹，胶原蛋白流失，皮肤柔韧性流失和它们的组合：
• Skin and Hair Restoration by Natural Amino Acid and Peptide Crown Complexes
  申请人：GUPTA SHYAM K.

  公开号：US20080287536A1

  公开（公告）日：2008-11-20

  This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related topical problems, for example, darkened skin including age spots, circles around eyes and stretch marks; skin conditions related to acne including excess facial oil and facial pore size; premature hair aging including hair loss and graying; inflammation including intra-cellular and extra-cellular inflammation; skin aging including wrinkles and fine lines; loss of collagen including thinning skin and loss of skin pliability; malfunction of tyrosinase group of enzymes; malfunction of matrix metalloprotease group of enzymes; and combinations thereof: Wherein, R, R′, and R″=any substituent(s); and M=H, Li, Na, K, Ca, Mg, Zn, Mn, Cu, Fe, Co, Mo, V, Cr, Ammonium, Alkyl ammonium, and Nitrogen Heterocyclic ammonium.

  本发明涉及一种公式（I）的天然氨基酸和肽衍生的某些皮肤和头发护理剂。这些剂提供了多功能的酶相关局部问题治疗，例如黑色皮肤，包括老年斑，眼周圆圈和妊娠纹; 与痤疮相关的皮肤状况，包括过多的面部油脂和面部毛孔大小; 早期头发老化，包括脱发和变白; 炎症，包括细胞内和细胞外炎症; 皮肤老化，包括皱纹和细纹; 胶原蛋白丢失，包括皮肤变薄和失去弹性; 酪氨酸酶类酶的功能障碍; 基质金属蛋白酶酶类的功能障碍; 以及它们的组合：其中，R，R'和R'' = 任何取代基; M = H，Li，Na，K，Ca，Mg，Zn，Mn，Cu，Fe，Co，Mo，V，Cr，铵，烷基铵和氮杂环铵。
• Process to obtain new mixed copper aminoacidate complexes from phenanthrolines and their alkyl derivatives to be used as anticancerigenic agents
  申请人：UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

  公开号：EP0434445A2

  公开（公告）日：1991-06-26

  This invention refers to a process to obtain new mixed copper aminoacidates from phenanthrolines and their alkyl derivates of an aromatic type to be used as anticancerigenic, agents preferably with a therapeutic use for the treatment of liquid and solid cancerigenic tumours such as leukemia. The complexes obtained are of the [Cu (N-N) (N-O)]⁺⁻ NO₃ type in which the N-N ligand corresponds to 4, 7-dimethyl-1, 10 phenanthroline and the N-O ligand preferably correponds to one of the aminoacidates such as tyrosine-alaninate, treoninate, triptophanate, valinate, isoleucinate, cisteinate, diglycinate, phenylalaninate, glycinate, hystidinate, serinate, tyrosinate, aspartate, alaninate and phenylalaninate. The process is characterized because it includes the following steps: making an aqueous solution based on an aliphatic alcohol and 4, 7-dimethyl-1, 10 phenanthroline react with a copper complex preferably CuNO₃5H₂O at room temperature, and immediately after making the obtained product react in an aqueous aminoacidate solution adjusting a slightly alkaline pH.

  本发明涉及一种从菲罗啉及其芳香族烷基衍生物中获得新的混合氨基酸铜的工艺，该工艺可用作抗癌剂，优选用于治疗液态和固态致癌肿瘤，如白血病。所获得的配合物为[Cu (N-N) (N-O)]⁺- NO₃型，其中 N-N 配体对应于 4，7-二甲基-1，10-菲罗啉，N-O 配体最好对应于氨基酸盐之一，如酪氨酸丙氨酸盐、曲安酸盐、三色氨酸盐、氨酸、三色氨酸、缬氨酸、异亮氨酸、肌氨酸、二甘氨酸、苯丙氨酸、甘氨酸、胱氨酸、丝氨酸、酪氨酸、天门冬氨酸、丙氨酸和苯丙氨酸。该工艺的特点是包括以下步骤：在室温下，使基于脂肪醇和 4，7-二甲基-1，10-菲罗啉的水溶液与铜络合物（最好是 CuNO₃5H₂O）反应，然后立即使得到的产物在调节 pH 值为微碱性的氨基酸水溶液中反应。
• Codon-optimized reduced-size ATP7A cDNA and uses for treatment of copper transport disorders
  申请人：The United States of America, as represented by the Secretary, Dept. of Health and Human Services

  公开号：US10988778B2

  公开（公告）日：2021-04-27

  Disclosed herein are codon-optimized nucleic acids encoding a reduced-size ATP7A protein. Also disclosed are vectors and recombinant viruses (such as recombinant adeno-associated viruses) including the codon-optimized nucleic acids encoding the reduced-size ATP7A protein and compositions including the disclosed vectors and viruses. Further disclosed herein are methods of treating copper transport disorders, for example by administering a disclosed nucleic acid, vector, or recombinant virus to a subject with a copper transport disorder, such as Menkes disease, occipital horn syndrome, or ATP7A-related distal motor neuropathy.

  本文公开了编码缩小尺寸 ATP7A 蛋白的密码子优化核酸。还公开了包括编码缩小尺寸 ATP7A 蛋白的密码子优化核酸的载体和重组病毒（如重组腺相关病毒）以及包括所公开载体和病毒的组合物。本文进一步公开了治疗铜转运障碍的方法，例如通过给患有铜转运障碍的受试者施用所公开的核酸、载体或重组病毒，如梅克斯病、枕角综合征或ATP7A相关的远端运动神经病。