5-phenyl-3-(thiophen-3-yl)-4,5-dihydro-1,2,4-oxadiazole | 1622348-59-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-phenyl-3-(thiophen-3-yl)-4,5-dihydro-1,2,4-oxadiazole
• 英文别名: 5-Phenyl-3-thiophen-3-yl-2,5-dihydro-1,2,4-oxadiazole；5-phenyl-3-thiophen-3-yl-2,5-dihydro-1,2,4-oxadiazole
• CAS: 1622348-59-7
• 化学式: C₁₂H₁₀N₂OS
• 分子量: 230.29
• InChiKey: GCVKFVNSFABPJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  61.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-phenyl-3-(thiophen-3-yl)-4,5-dihydro-1,2,4-oxadiazole 在 苯甲醛 、 sodium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 21.0h， 以75 mg的产率得到5-phenyl-3-(thiophen-3-yl)-1,2,4-oxadiazole
  参考文献：
  名称：

  Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Amidoximes and Aldehydes in the Superbasic System NaOH/DMSO

  摘要：

  A new procedure has been proposed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles by reaction of amidoximes with aldehydes in the superbasic system NaOH/DMSO at room temperature. The scope of the proposed procedure has been demonstrated by 15 syntheses from various amidoximes and aromatic aldehydes with 27-76% yields. The procedure is inapplicable to aliphatic aldehydes.

  DOI：

  10.1134/s107042802007009x
• 作为产物：
  描述：

  噻吩-3-甲胺肟 、 苯甲醛 在 sodium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 生成 5-phenyl-3-(thiophen-3-yl)-4,5-dihydro-1,2,4-oxadiazole
  参考文献：
  名称：

  Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Amidoximes and Aldehydes in the Superbasic System NaOH/DMSO

  摘要：

  A new procedure has been proposed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles by reaction of amidoximes with aldehydes in the superbasic system NaOH/DMSO at room temperature. The scope of the proposed procedure has been demonstrated by 15 syntheses from various amidoximes and aromatic aldehydes with 27-76% yields. The procedure is inapplicable to aliphatic aldehydes.

  DOI：

  10.1134/s107042802007009x

文献信息

• 3,5-DISUBSTITUTED-4,5-DIHYDRO-1,2,4-OXADIAZOLES AND COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS
  申请人：Monsanto Technology LLC

  公开号：US20140235439A1

  公开（公告）日：2014-08-21

  Provided herein are new 3,5-disubstituted-4,5-dihydro-1,2,4-oxadiazoles that exhibit nematicidal activity and are useful, for example, in compositions and methods for the control of unwanted nematodes.

  本文提供了一种新的3,5-二取代-4,5-二氢-1,2,4-噁二唑，具有线虫杀活性，并可用于控制不需要的线虫的组合物和方法中。
• 3,5-DISUBSTITUTED-4,5-DIHYDRO-1,2,4-OXADIAZOLES FOR CONTROLLING NEMATODE PESTS
  申请人：Monsanto Technology LLC

  公开号：EP2956453A1

  公开（公告）日：2015-12-23
• US9232800B2
  申请人：——

  公开号：US9232800B2

  公开（公告）日：2016-01-12
• [EN] 3,5-DISUBSTITUTED-4,5-DIHYDRO-1,2,4-OXADIAZOLES FOR CONTROLLING NEMATODE PESTS<br/>[FR] 4,5-DIHYDRO-1,2,4-OXADIAZOLES 3,5-DISUBSTITUÉS POUR LA LUTTE CONTRE LES ORGANISMES NUISIBLES DE NÉMATODE
  申请人：MONSANTO TECHNOLOGY LLC

  公开号：WO2014127195A1

  公开（公告）日：2014-08-21

  Provided herein are new 3,5-disubstituted-4,5-dihydro-1,2,4-oxadiazoles that exhibit nematicidal activity and are useful, for example, in compositions and methods for the control of unwanted nematodes.