4-Carboxy-cyclohexan-1,1-diessigsaeure | 10428-80-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-Carboxy-cyclohexan-1,1-diessigsaeure
• 英文别名: 4,4-bis(carboxymethyl)cyclohexane-1-carboxylic Acid
• CAS: 10428-80-5
• 化学式: C₁₁H₁₆O₆
• 分子量: 244.244
• InChiKey: FJPATRZRCOLKEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-Carboxy-cyclohexan-1,1-diessigsaeure 在 lithium aluminium tetrahydride 、 硫酸 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 9-Hydroxymethyl-1,1-bis-(β-hydroxyaethyl)-cyclohexan
  参考文献：
  名称：

  Spirans. XIII. 3,9-Disubstituted Spiro[5.5]undecane Compounds

  摘要：

  DOI：

  10.1021/jo01281a602
• 作为产物：
  描述：

  1,5-Dicyano-9-carboxy-3-azaspiro<5.5>undecan-2,4-dion 生成 4-Carboxy-cyclohexan-1,1-diessigsaeure
  参考文献：
  名称：

  Spirans. XIII. 3,9-Disubstituted Spiro[5.5]undecane Compounds

  摘要：

  DOI：

  10.1021/jo01281a602

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2020252396A1

  公开（公告）日：2020-12-17

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral RSV F protein (e.g., Presatovir, MDT 637, JNJ 179, or an analog thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., RSV infections).

  用于治疗病毒感染的组合物和方法包括含有病毒RSV F蛋白抑制剂（例如Presatovir、MDT 637、JNJ 179或其类似物）的共轭物，连接到一个Fc单体、一个Fc结构域和Fc结合肽、一种白蛋白蛋白质或白蛋白结合肽。特别是，这些共轭物可以用于治疗病毒感染（例如RSV感染）。
• Degradable polymer and preparation process of the same
  申请人：MITSUI TOATSU CHEMICALS, INC.

  公开号：EP0829503A2

  公开（公告）日：1998-03-18

  The invention relates to a degradable polymer and a process for preparing of the degradable polymer which has a structure resulting from combination of a star-shaped polymer comprising a polyfunctional center compound of polycarboxylic acid having three or more carboxyl groups and/or anhydride of the same or aliphatic polyhydric alcohol having three or more hydroxyl groups and a unit of aliphatic hydroxycarboxylic acid, through aliphatic polyhydric alcohol having two or more hydroxyl groups or polycarboxylic acid having two or more carboxyl groups or anhydrides of the same. The degradable polymer of the invention leads to remarkably low coloration as compared with a polymer comprising polysaccharide as a polyfunctional center compound, has high melt tension as compared to common aliphatic polyester is excellent in processability on various molding methods, foam molding and blow molding in particular, and high transparency.

  本发明涉及一种可降解聚合物和制备该可降解聚合物的工艺，该聚合物的结构由星形聚合物组合而成，星形聚合物由具有三个或三个以上羧基的聚羧酸和（或）具有三个或三个以上羧基的聚羧酸酸酐或具有三个或三个以上羟基的脂肪族多元醇的多官能团中心化合物和脂肪族羟基羧酸单元组成、具有两个或两个以上羟基的脂肪族多元醇或具有两个或两个以上羧基的聚羧酸或其酸酐。 与包含多糖作为多官能团中心化合物的聚合物相比，本发明的可降解聚合物的着色率明显较低；与普通脂肪族聚酯相比，本发明的可降解聚合物具有较高的熔体张力，在各种成型方法（尤其是发泡成型和吹塑成型）上都具有出色的可加工性和较高的透明度。
• Composite resin composition
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0897943A2

  公开（公告）日：1999-02-24

  The invention provides a composite resin composition comprising an aliphatic polyester resin (component A) having aliphatic hydroxycarboxylic acid units, one or more biomass materials (component B) selected from the group consisting of cellulose, lignocellulose and starch and an unsaturated carboxylic acid or a derivative thereof (component C), wherein the composite resin composition comprises a component obtained by covalently bonding a portion or the whole of component A and component B through component C. On processing into various formed items, the composite resin composition of the invention exhibits excellent tensile strength and other physical properties and processability and simultaneously has good biodegradability, and enables biomass materials of low added value to be applied for high added value uses in a large amount.

  本发明提供了一种复合树脂组合物，包括具有脂肪族羟基羧酸单元的脂肪族聚酯树脂（组分A）、选自纤维素、木质纤维素和淀粉组成的组中的一种或多种生物质材料（组分B）以及不饱和羧酸或其衍生物（组分C），其中复合树脂组合物包括通过组分C共价键合组分A和组分B的一部分或全部而得到的组分。在加工成各种成型物品时，本发明的复合树脂组合物表现出优异的拉伸强度和其他物理性能及加工性能，同时具有良好的生物降解性，可使低附加值的生物质材料大量用于高附加值用途。
• Process for preparing aliphatic hydroxycarboxylic acid polyesters
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0953589A2

  公开（公告）日：1999-11-03

  The invention provides a process for producing high-molecular aliphatic polyesters capable of being substitutes for general-purpose resins that are required to have high toughness, in a simplified manner and at a high volume efficiency. Specifically, in the process, used as the starting material is an easily-available, low-molecular aliphatic polyester prepolymer to be prepared through polycondensation of inexpensive materials of an aliphatic hydroxycarboxylic acid such as lactic acid, glycollic acid or the like, an aliphatic polyalcohol such as butanediol or the like, and an aliphatic polycarboxylic acid such as succinic acid or the like, and the starting prepolymer is crystallized and thereafter polycondensed in a solid phase in the presence of a catalyst to give the intended, tough and high-molecular aliphatic polyester.

  本发明提供了一种生产高分子脂肪族聚酯的工艺，该工艺能够以简化的方式和较高的生产效率生产出高韧性通用树脂的替代品。具体来说，在该工艺中，作为起始材料的是一种易于获得的低分子脂肪族聚酯预聚物，该预聚物可通过脂肪族羟基羧酸（如乳酸、羟基乙酸或类似物质）的廉价材料缩聚而制备、脂肪族多元醇（如丁二醇或类似物）和脂肪族聚羧酸（如琥珀酸或类似物），将起始预聚物结晶，然后在催化剂存在下在固相中缩聚，得到所需的坚韧的高分子脂肪族聚酯。
• HEAT CARRIER COMPOSITION
  申请人：Shishiai-Kabushikigaisha

  公开号：EP1829949A1

  公开（公告）日：2007-09-05

  The present invention provides a pH stabilizing heat transfer medium composition comprising a main component of water, glycol, alcohol or glycol ether, and a pH buffer agent. The pH buffer agent is comprised of an alicyclic compound where a single ring-constituting carbon atom is bonded to two identical members or two different members selected from the group consisting of carboxymethyl and its salts, or where at least two ring-constituting neighboring carbon atoms are each bonded to a single member selected from the group consisting of carboxymethyl and its salts.

  本发明提供了一种 pH 值稳定传热介质组合物，其主要成分包括水、乙二醇、醇或乙二醇醚以及 pH 值缓冲剂。pH 缓冲剂由脂环族化合物组成，其中单个构环碳原子与两个相同的成员或两个不同的成员键合，这些成员选自羧甲基及其盐组成的组，或者至少两个构环相邻碳原子分别与单个成员键合，这些成员选自羧甲基及其盐组成的组。