2-(dimethylamino)-4,5-dimethoxy-benzaldehyde | 62970-08-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(dimethylamino)-4,5-dimethoxy-benzaldehyde
• 英文别名: 6-Dimethylaminoveratraldehyd；6-Dimethylaminoveratraldehyde；2-(dimethylamino)-4,5-dimethoxybenzaldehyde
• CAS: 62970-08-5
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: ZEQBOZAFLBEOKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(dimethylamino)-4,5-dimethoxy-benzaldehyde 生成 6-Dimethylaminoveratraldehyd-methojodid
  参考文献：
  名称：

  COWLAGI B. S.; DAVE M. A.; KULKARNI A. B., INDIAN J. CHEM., 1976, B14, NO 11, 904-905

  摘要：

  DOI：
• 作为产物：
  描述：

  6-氟藜芦醛 、 二甲胺 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 2-(dimethylamino)-4,5-dimethoxy-benzaldehyde
  参考文献：
  名称：

  Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles

  摘要：

  DOI：

  10.1021/acs.orglett.1c02816

文献信息

• ANTI-HIV COMPOUNDS
  申请人：Prosetta Antiviral, Inc.

  公开号：US20160168100A1

  公开（公告）日：2016-06-16

  This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.

  这项发明提供了用于治疗病毒感染的四氢异喹啉等化合物，含有这类化合物的药物配方，以及抑制病毒（如HIV）复制或治疗疾病（如艾滋病）的方法。
• Chemo-, Regio-, and Stereoselective Trifluoromethylation of Styrenes via Visible Light-Driven Single-Electron Transfer (SET) and Triplet–Triplet Energy Transfer (TTET) Processes
  作者：Qing-Yu Lin、Xiu-Hua Xu、Feng-Ling Qing

  DOI：10.1021/jo502040t

  日期：2014.11.7

  A process for tunable and chemo-, regio-, and stereoselective photocatalytic trifluoromethylation of styrenes was developed. Thermodynamically stable E-trifluoromethylated alkenes were prepared using Togni’s reagent in the presence of Ru(bpy)3Cl2·6H2O under visible light irradiation, whereas less thermodynamically stable Z-trifluoromethylated alkenes were obtained by employing Umemoto’s reagent and

  开发了一种可调谐的，化学的，区域的和立体选择性的苯乙烯光催化三氟甲基化方法。热力学稳定Ë -trifluoromethylated使用TOGNI的试剂中的Ru（联吡啶）的存在下制备烯烃3氯2 ·6H 2 o在可见光照射，而热力学较不稳定的Ž -trifluoromethylated通过采用梅本试剂和光催化剂的Ir得到烯烃（PPY ）3。
• 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds
  申请人：Prosetta Antiviral, Inc.

  公开号：US10195189B2

  公开（公告）日：2019-02-05

  This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.

  除其他外，本发明还提供了用于治疗病毒感染的四氢异喹啉类化合物、含有此类化合物的药物制剂，以及抑制艾滋病毒等病毒复制或治疗艾滋病等疾病的方法。
• Schoepf; Thierfelder, Justus Liebigs Annalen der Chemie, 1932, vol. 497, p. 22,33
  作者：Schoepf、Thierfelder

  DOI：——

  日期：——
• 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS
  申请人：Prosetta Antiviral, Inc.

  公开号：US20170368051A1

  公开（公告）日：2017-12-28

  This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.