(2-bromo-4-methoxyphenyl)(4-methylphenyl)methanol | 1253376-59-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-bromo-4-methoxyphenyl)(4-methylphenyl)methanol
• 英文别名: (2-Bromo-4-methoxyphenyl)-(4-methylphenyl)methanol
• CAS: 1253376-59-8
• 化学式: C₁₅H₁₅BrO₂
• 分子量: 307.187
• InChiKey: XFBXUYZFQRRRAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-bromo-4-methoxyphenyl)(4-methylphenyl)methanol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 以53%的产率得到(2-bromo-4-methoxyphenyl)(4-methylphenyl)methanone
  参考文献：
  名称：

  Synthesis of 3-Substituted Benzo[b]thiophenes via the Reaction of α-Substituted 2-Lithio-β-methoxystyrenes with Sulfur

  摘要：

  3-Substitued benzo[b]thiophenes were synthesized in reasonable overall yields from alpha-substituted 2-bromo-beta-methoxystyrenes. Thus, the bromine-lithium exchange between these bromostyrenes with butyllithium in diethyl ether at 0 degrees C followed by reaction with sulfur afforded the corresponding a-substituted beta-methoxy-2-sulfanylstyrenes. These were then treated with an equimolar amount of concentrated hydriodic acid in acetonitrile at room temperature to give the desired products.

  DOI：

  10.3987/com-10-11970
• 作为产物：
  描述：

  2-溴-4-甲氧基苯甲醛 、 对甲苯基溴化镁 以 四氢呋喃 为溶剂， 以92%的产率得到(2-bromo-4-methoxyphenyl)(4-methylphenyl)methanol
  参考文献：
  名称：

  Synthesis of 3-Substituted Benzo[b]thiophenes via the Reaction of α-Substituted 2-Lithio-β-methoxystyrenes with Sulfur

  摘要：

  3-Substitued benzo[b]thiophenes were synthesized in reasonable overall yields from alpha-substituted 2-bromo-beta-methoxystyrenes. Thus, the bromine-lithium exchange between these bromostyrenes with butyllithium in diethyl ether at 0 degrees C followed by reaction with sulfur afforded the corresponding a-substituted beta-methoxy-2-sulfanylstyrenes. These were then treated with an equimolar amount of concentrated hydriodic acid in acetonitrile at room temperature to give the desired products.

  DOI：

  10.3987/com-10-11970

文献信息

• [EN] NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF<br/>[FR] COMPOSÉ MACROCYCLIQUE AZOTÉ, SON PROCÉDÉ DE PRÉPARATION, SA COMPOSITION PHARMACEUTIQUE ET SON APPLICATION<br/>[ZH] 一种含氮大环类化合物、其制备方法、药物组合物及应用
  申请人：SHANDONG LUOXIN PHARMACY STOCK

  公开号：WO2018086605A1

  公开（公告）日：2018-05-17

  本发明公开了一种含氮大环类化合物、其制备方法、药物组合物及应用。本发明提供了一种如式III-0所示的含氮大环类化合物、其互变异构体、其光学异构体、其水合物、其溶剂化物、其药学上可接受的盐或其前药。该化合物可有效地结合BET家族BRD4、BRD3、BRD2和BRDT的溴结构域，以调控下游基因c-myc和其相关靶基因的转录，进而调节下游的信号通路，发挥特定作用，包括治疗疾病如炎性疾病、癌症和AIDS。
• Synthesis of 3-Substituted Benzo[b]thiophenes via the Reaction of α-Substituted 2-Lithio-β-methoxystyrenes with Sulfur
  作者：Kazuhiro Kobayashi、Daisuke Nakai、Shuhei Fukamachi、Hisatoshi Konishi

  DOI：10.3987/com-10-11970

  日期：——

  3-Substitued benzo[b]thiophenes were synthesized in reasonable overall yields from alpha-substituted 2-bromo-beta-methoxystyrenes. Thus, the bromine-lithium exchange between these bromostyrenes with butyllithium in diethyl ether at 0 degrees C followed by reaction with sulfur afforded the corresponding a-substituted beta-methoxy-2-sulfanylstyrenes. These were then treated with an equimolar amount of concentrated hydriodic acid in acetonitrile at room temperature to give the desired products.