5-溴-2,3-二甲氧基甲苯 | 58005-60-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-溴-2,3-二甲氧基甲苯
• 英文名称: 5-bromo-2,3-dimethoxytoluene
• 英文别名: 5-Bromo-1,2-dimethoxy-3-methylbenzene
• CAS: 58005-60-0
• 化学式: C₉H₁₁BrO₂
• 分子量: 231.089
• InChiKey: UHFGAEIJDUGRHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-溴-2,3-二甲氧基甲苯 在 氢氧化钾 、 N-溴代丁二酰亚胺(NBS) 、 aluminum tri-bromide 、 偶氮二异丁腈 作用下， 以 四氯化碳 、 乙醇 、 苯 为溶剂， 反应 16.0h， 生成 5-bromo-2,3-dihydroxyphenylacetic acid
  参考文献：
  名称：

  Daukshas, V. K.; Martinkus, R. S.; Kuleshyus, V. A., Journal of Organic Chemistry USSR (English Translation), 1983, vol. 19, p. 458 - 463

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-4,5-二甲氧基苯胺 在 硫酸 、 铜 、 copper(II) sulfate 、 sodium bromide 、 sodium nitrite 作用下， 生成 5-溴-2,3-二甲氧基甲苯
  参考文献：
  名称：

  Daukshas, V. K.; Martinkus, R. S.; Kuleshyus, V. A., Journal of Organic Chemistry USSR (English Translation), 1983, vol. 19, p. 458 - 463

  摘要：

  DOI：

文献信息

• Propionic Acid Derivatives and Methods of Use Thereof
  申请人：Biediger Ronald J.

  公开号：US20180312523A1

  公开（公告）日：2018-11-01

  Provided herein are compounds and pharmaceutical compositions of formula I where R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

  本文提供了公式I的化合物和药物组合物，其中R1、R2、R3、R4、R5和R6如本文所述。还提供了这些化合物的药用可接受盐或立体异构体。此外，还提供了用于抑制整合素结合以治疗各种病理生理条件的方法。
• PROCESS FOR PRODUCTION OF OXIDATION REACTION PRODUCT OF AROMATIC COMPOUND
  申请人：Ohkubo Kei

  公开号：US20120171111A1

  公开（公告）日：2012-07-05

  The present invention provides a process for producing an oxidation reaction product of an aromatic compound, having excellent environmental load reduction performance, cost reduction performance, etc. Provided is a process for producing an oxidation reaction product of a raw material aromatic compound by reacting the raw material aromatic compound with an oxidizing agent. The process further uses an electron donor-acceptor linked molecule. The process includes the step of: reacting the electron donor-acceptor linked molecule in an electron-transfer state, the oxidizing agent, and the raw material aromatic compound, thereby generating an oxidation reaction product resulting from oxidation of the raw material aromatic compound.

  本发明提供了一种生产芳香化合物氧化反应产物的工艺，具有优异的环境负荷减少性能、成本降低性能等。提供了一种通过将原料芳香化合物与氧化剂反应来生产原料芳香化合物的氧化反应产物的工艺。该工艺进一步使用了电子给体-受体连接分子。该工艺包括以下步骤：在电子转移状态下将电子给体-受体连接分子、氧化剂和原料芳香化合物反应，从而生成由原料芳香化合物氧化产生的氧化反应产物。
• [EN] TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5<br/>[FR] MODULATEURS TÉTRAHYDRO-BENZOIMIDAZOLYLES DE TGR5
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2015160772A1

  公开（公告）日：2015-10-22

  The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, X, Z1and Z2 are defined in the specification.

  本发明包括式（I）的化合物。其中：R1、R2、R3、R4、R5、R6、R7、R8、X、Z1和Z2在规范中定义。
• ORGANIC LIGHT-EMITTING DIODES COMPRISING AT LEAST ONE DISILYL COMPOUND SELECTED FROM DISILYLCARBAZOLES, DISILYLDIBENZOFURANS, DISILYLDIBENZOTHIOPHENES, DISILYLDIBENZOPHOLES, DISILYLDIBENZOTHIOPHENE S-OXIDES AND DISILYLDIBENZOTHIOPHENE S,S-DIOXIDES
  申请人：Langer Nicolle

  公开号：US20110031477A1

  公开（公告）日：2011-02-10

  The present invention relates to an organic light-emitting diode comprising an anode An and a cathode Ka and a light-emitting layer E and if appropriate at least one further layer, where the light-emitting layer E and/or the at least one further layer comprises at least one compound selected from disilylcarbazoles, disilyldibenzofurans, disilyldibenzothiophenes, disilyldibenzophospholes, disilyldibenzothiophene S-oxides and disilyldibenzothiophene S,S-dioxides, to a light-emitting layer comprising at least one of the aforementioned compounds, to the use of the aforementioned compounds as matrix material, hole/exciton blocker material, electron/exciton blocker material, hole injection material, electron injection material, hole conductor material and/or electron conductor material, and to a device selected from the group consisting of stationary visual display units, mobile visual display units and illumination units comprising at least one inventive organic light-emitting diode.

  本发明涉及一种有机发光二极管，包括阳极An和阴极Ka以及发光层E，如适当的至少一层，其中发光层E和/或至少一层包括至少一种选择自二硅基咔唑、二硅基二苯并呋喃、二硅基二苯并噻吩、二硅基二苯并磷杂环戊二烯、二硅基二苯并噻吩S-氧化物和二硅基二苯并噻吩S,S-二氧化物的化合物，至少包括上述化合物之一的发光层，使用上述化合物作为基质材料、空穴/激子阻挡材料、电子/激子阻挡材料、空穴注入材料、电子注入材料、空穴传导材料和/或电子传导材料，并选择自固定的视觉显示单元、移动的视觉显示单元和包括至少一个创新有机发光二极管的照明单元的设备。
• MOLECULAR GLASS OF SPIROFLUORENE DERIVATIVE, PREPARATION METHOD THEREOF AND USE THEREOF IN PHOTO-ETCHING
  申请人：TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES

  公开号：US20150353468A1

  公开（公告）日：2015-12-10

  Disclosed is a molecular glass of a spirofluorene derivative having a molecular structure as follows: formula (I), wherein each of R 1 -R 12 is a hydrogen atom, a hydroxyl group, a methoxyl group or an acid-sensitive substituent; substituents R 1 ˜R 12 can be identical or different, but on the same benzene ring the substituents cannot all be hydrogen atoms. The molecular glass has a good solubility in various polar solvents, is suitable to be made into a film; meanwhile the molecular glass has a very high glass transition temperature and meets the requirements of the photolithography processing technology. Also disclosed is a preparation method of the above-mentioned molecular glass of a spirofluorene derivative. The synthetic process of the method is simple and suitable for industrialization. Further disclosed is the use of a photo-resist with the above-mentioned molecular glass as a main material in photo-etching, wherein the molecular glass of a spirofluorene derivative with hydroxyl groups (or partly with hydroxyl groups) on the periphery thereof can be used as a negative photo-resist, and the molecular glass with the hydroxyl groups on the periphery thereof protected (or partly protected) by an acid-sensitive substituent can be used as a positive photo-resist.

  揭示了一种螺氟萘衍生物的分子玻璃，其分子结构如下：式（I），其中R1-R12中的每一个是氢原子、羟基、甲氧基或酸敏感取代基；取代基R1～R12可以相同也可以不同，但在同一苯环上，取代基不能全为氢原子。该分子玻璃在各种极性溶剂中具有良好的溶解性，适用于制成薄膜；同时，该分子玻璃具有非常高的玻璃转变温度，符合光刻工艺技术的要求。还公开了上述螺氟萘衍生物的分子玻璃的制备方法。该方法的合成过程简单，适合工业化生产。进一步公开了将上述分子玻璃作为主要材料的光刻用光刻胶的用途，其中，带有羟基（或部分带有羟基）的螺氟萘衍生物分子玻璃可用作负光刻胶，而带有酸敏感取代基保护的（或部分保护的）带有羟基的螺氟萘衍生物分子玻璃可用作正光刻胶。