Benzyl-[2-(4-phenoxy-phenyl)-ethyl]-amine | 185051-62-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl-[2-(4-phenoxy-phenyl)-ethyl]-amine
• 英文别名: N-benzyl-2-(4-phenoxyphenyl)ethanamine
• CAS: 185051-62-1
• 化学式: C₂₁H₂₁NO
• 分子量: 303.404
• InChiKey: AOHOJNHKIRSXBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Benzyl-[2-(4-phenoxy-phenyl)-ethyl]-amine 在 platinum(IV) oxide 氢气 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 生成 (R)-1-(3-Amino-4-benzyloxy-phenyl)-2-{benzyl-[2-(4-phenoxy-phenyl)-ethyl]-amino}-ethanol
  参考文献：
  名称：

  Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the β2-adrenoceptor activity

  摘要：

  The synthesis of a series of long-chain formoterol analogues in which the terminal ether residue of the beta-phenethyl-amino-substituent has been extended beyond the methyl ether residue present in the parent compound are described. Evaluation of these analogues as beta(2)-adrenoceptor agonists was used to provide an insight into the factors controlling the magnitude and duration of receptor activation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.086
• 作为产物：
  描述：

  4-苯氧基苯乙胺 在 lithium aluminium tetrahydride 作用下， 生成 Benzyl-[2-(4-phenoxy-phenyl)-ethyl]-amine
  参考文献：
  名称：

  Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the β2-adrenoceptor activity

  摘要：

  The synthesis of a series of long-chain formoterol analogues in which the terminal ether residue of the beta-phenethyl-amino-substituent has been extended beyond the methyl ether residue present in the parent compound are described. Evaluation of these analogues as beta(2)-adrenoceptor agonists was used to provide an insight into the factors controlling the magnitude and duration of receptor activation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.086

文献信息

• Hydroalkylation of Styrenes with Benzylamines by Potassium Hydride
  作者：Jia Hao Pang、Bin Wang、Kohei Watanabe、Ryo Takita、Shunsuke Chiba

  DOI：10.1002/hlca.202100120

  日期：2021.10

  A method for the synthesis of 1,3-diarylpropylamines through hydroalkylation of styrenes with benzylamines by potassium hydride has been developed. The protocol is initiated by solvothermal treatment of benzylamines with KH at 100 °C to generate deprotonated anionic species, which undergo selective C-alkylation with arylalkenes at 0 °C to ambient temperature to afford 1,3-diarylpropylamines as the

  开发了一种通过氢化钾使苯乙烯与苄胺加氢烷基化合成 1,3-二芳基丙胺的方法。该协议通过在 100°C 下用 KH 对苄胺进行溶剂热处理以生成去质子化的阴离子物质，在 0°C 至环境温度下与芳基烯烃进行选择性 C-烷基化，以提供 1,3-二芳基丙胺作为主要产品。
• [EN] BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE<br/>[FR] DERIVES DE BENZENE, PYRIDINE, NAPHTALENE OU BENZOPHENONE UTILISES COMME INHIBITEURS DE LA SQUALENE SYNTHETASE ET DE LA PROTEINE FARNESYLTRANSFERASE
  申请人：ABBOTT LABORATORIES

  公开号：WO1996034851A1

  公开（公告）日：1996-11-07

  (EN) The present invention provides a compound of formula (I), (II), (III) or (IV), processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using the compounds of the invention.(FR) La présente invention se rapporte à des composés de la formule (I), (II), (III) ou (IV), aux procédés de préparation de ces composés, aux intermédiaires utilisés dans ces procédés, à une composition pharmaceutique et aux procédés d'utilisation de ces composés.

  该发明提供了公式（I），（II），（III）或（IV）的化合物，制备该发明化合物的方法，这些方法中有用的中间体，制药组合物以及使用该发明化合物的方法。