3-[2-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]propanal;hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-[2-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]propanal;hydrochloride
• 英文别名: 3-[2-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]propanal;hydrochloride
• 化学式: C17H27ClN2O2
• 分子量: 326.9
• InChiKey: UJLBPFHMIVYUGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.26
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHODS OF TREATING MUSCULAR DYSTROPHY
  申请人：The Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno

  公开号：EP2892525A1

  公开（公告）日：2015-07-15
• [EN] METHODS OF TREATING MUSCULAR DYSTROPHY<br/>[FR] MÉTHODES DE TRAITEMENT DE LA DYSTROPHIE MUSCULAIRE
  申请人：UNIV NEVADA

  公开号：WO2014040077A1

  公开（公告）日：2014-03-13

  Disclosed herein are α7β1 integrin modulatory agents and methods of using such to treat conditions associated with decreased α7β1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an α7β1 integrin modulatory agent to the subject with muscular dystrophy, wherein the α7β1 integrin modulatory agent increases α7β1 integrin expression or activity as compared to α7β1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing α7β1 integrin expression by use of the disclosed α7β1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.