2-[3-[(E)-(benzo[e][1]benzofuran-2-carbonylhydrazinylidene)methyl]-2-methylindol-1-yl]butanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 2-[3-[(E)-(benzo[e][1]benzofuran-2-carbonylhydrazinylidene)methyl]-2-methylindol-1-yl]butanoic acid
• 化学式: C₂₇H₂₃N₃O₄
• 分子量: 453.5
• InChiKey: XFLZBKZPIAEYGQ-RWPZCVJISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  96.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• ANTI-INFLAMMATORY COMPOSITION COMPRISING ACYLHYDRAZONE DERIVATIVE
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：EP3747436A1

  公开（公告）日：2020-12-09

  The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.

  本发明涉及一种用于预防、缓解或治疗炎症性疾病的组合物，其作为活性成分包含酰基腙衍生物化合物、其立体异构体或其药学上可接受的盐。本发明的酰基腙衍生物化合物、其立体异构体或其药学上可接受的盐可有效抑制炎症细胞因子和炎症信号通路，从而有效缓解皮炎等炎症性疾病的症状。因此，根据本发明的组合物可有效地用于预防、缓解或治疗炎症性疾病。
• COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER COMPRISING N-METHYLENENAPHTHO[2,1-b]FURAN-2-CARBOHYDRAZIDE DERIVATIVES AS AN ACTIVE INGREDIENT
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US20150182502A1

  公开（公告）日：2015-07-02

  The present invention relates to ethyl(2-methyl-3(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.
• US9433607B2
  申请人：——

  公开号：US9433607B2

  公开（公告）日：2016-09-06
• [EN] ETHYL(2-METHYL-3{(E)-[(NAPHTHA[2,1-B]FURAN-2-YLCARBONYL)HYDRAZONO]METHYL}-1H-INDOLE-1-YL)ACETATE, AND COMPOSITION COMPRISING ANALOGUES THEREOF AS ACTIVE COMPONENT, FOR PREVENTING AND TREATING CANCER<br/>[FR] (2-MÉTHYL-3{(E)-[(NAPHTA[2,1-B]FURAN-2-YLCARBONYL)HYDRAZONO]MÉTHYL}-1H- INDOLE-1-YL)ACÉTATE D'ÉTHYLE, ET COMPOSITION COMPRENANT DES ANALOGUES DE CELUI-CI POUR LA PRÉVENTION ET LE TRAITEMENT DU CANCER
  申请人：KOREA RES INST OF BIOSCIENCE

  公开号：WO2014038894A1

  公开（公告）日：2014-03-13

  본 발명은 신규한 세포 유사분열 저해제인 에틸(2 - 메틸 - 3 - (E) - [(나프타[2,1-b]퓨란-2-일카보닐)하이드라조노]메틸} - 1H - 인돌 - 1 - 일)아세테이트에 관한 것이다. 에틸(2 - 메틸 - 3 - (E) - [(나프타[2, 1 - b]퓨란 - 2 - 일카보닐)하이드라조노]메틸} - 1H - 인돌 - 1 - 일)아세테이트는 유사분열 과정에서 튜불린의 중합을 저해하여 세포자살을 유도한다. 또한 다제약 내성을 보이는 암세포에도 효과가 우수하다. 따라서 다양한 암을 비롯한 세포증식성 질병의 치료에 중요하게 이용될 수 있다.