2-[(Dimethylamino)methyl]hexadecane-1-sulfonic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 2-[(Dimethylamino)methyl]hexadecane-1-sulfonic acid
• 英文别名: 2-[(dimethylamino)methyl]hexadecane-1-sulfonic acid
• 化学式: C₁₉H₄₁NO₃S
• 分子量: 363.6
• InChiKey: QWODTHMQBGBIMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] IRON CHELATORS AND USE THEREOF FOR REDUCING TRANSPLANT FAILURE<br/>[FR] CHÉLATEURS DU FER ET LEUR UTILISATION POUR LA RÉDUCTION D'ÉCHEC DE TRANSPLANTATION
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2014036414A2

  公开（公告）日：2014-03-06

  Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.