2-(4-fluoro-N-pentylanilino)acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(4-fluoro-N-pentylanilino)acetic acid
• 化学式: C₁₃H₁₈FNO₂
• 分子量: 239.29
• InChiKey: ANDYLRSSSWNTDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PRODUCTION OF ENANTIOMERICALLY PURIFIED AMINO ACIDS
  申请人：Baxter Scott

  公开号：US20140065679A1

  公开（公告）日：2014-03-06

  The present application relates to a mutated Amycoiatopsis sp. TS-1-60 NAAAR that shows improved activity of the enzyme compared with the wild type Amycoiatopsis sp. TS-1-60 NAAAR. The mutated NAAAR is almost five times more active than its wild type counterpart. The present application also relates to the use of mutated Amycoiatopsis sp. TS-1-60 NAAAR in the production of enantiomerically pure amino acid from its N-acyl derivative via dynamic kinetic resolution method.