(7E,9E,11E,13E,17E)-2-hydroxyicosa-7,9,11,13,17-pentaenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (7E,9E,11E,13E,17E)-2-hydroxyicosa-7,9,11,13,17-pentaenoic acid
• 化学式: C₂₀H₃₀O₃
• 分子量: 318.4
• InChiKey: PAUCVWWRJKUFCI-ZBGHSBPNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] COMPOUNDS AND METHODS FOR MODULATING VASCULAR INJURY<br/>[FR] COMPOSÉS ET MÉTHODES DE MODULATION DE BLESSURES VASCULAIRES
  申请人：UNIV CALIFORNIA

  公开号：WO2014039964A2

  公开（公告）日：2014-03-13

  Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that find use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions find use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g., restenosis), and applications related to chronic inflammatory diseases of the vascular wall.