2-[4,7-Bis(carboxymethyl)-10-[2-(didecylamino)-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid;1,1,2-trichloroethene

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[4,7-Bis(carboxymethyl)-10-[2-(didecylamino)-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid;1,1,2-trichloroethene
• 英文别名: 2-[4,7-bis(carboxymethyl)-10-[2-(didecylamino)-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid;1,1,2-trichloroethene
• 化学式: C38H70Cl3N5O7
• 分子量: 815.3
• InChiKey: DLQYPVMGJIZLKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.07
• 重原子数：
  53
• 可旋转键数：
  26
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  145
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• PARAMAGNETIC SOLID LIPID NANOPARTICLES (PSLNS) CONTAINING METAL AMPHIPHILIC COMPLEXES FOR MRI
  申请人：Bracco Imaging S.p.A

  公开号：EP2892570A2

  公开（公告）日：2015-07-15
• [EN] PARAMAGNETIC SOLID LIPID NANOPARTICLES (PSLNS) CONTAINING METAL AMPHIPHILIC COMPLEXES FOR MRI.<br/>[FR] NANOPARTICULES LIPIDIQUES SOLIDES PARAMAGNÉTIQUES (PSLN) CONTENANT DES COMPLEXES AMPHIPHILES MÉTALLIQUES POUR IMAGERIE PAR RÉSONANCE MAGNÉTIQUE (IRM)
  申请人：BRACCO IMAGING SPA

  公开号：WO2014037498A2

  公开（公告）日：2014-03-13

  The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.