N-benzyl-2-[5-(4-morpholin-4-ylphenyl)pyridin-2-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-benzyl-2-[5-(4-morpholin-4-ylphenyl)pyridin-2-yl]acetamide
• 化学式: C₂₄H₂₅N₃O₂
• 分子量: 387.5
• InChiKey: AVAGKPGENLVOQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• COMPOSITION AND METHODS FOR MODULATING A KINASE CASCADE
  申请人：Athenex, Inc.

  公开号：US20180170875A1

  公开（公告）日：2018-06-21

  The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention also relates to substantially pure compound 1 and substantially pure compound 1 salt (e.g., compound 1 hydrochloride salt and compound 1 benzenesulfonate salt). The invention further relates to methods of preparing substantially pure compound 1 and compound 1 salts.

  本发明涉及化合物和方法，用于调节激酶级联的一个或多个组分。本发明还涉及实质上纯的化合物1和实质上纯的化合物1盐（例如，化合物1盐酸盐和化合物1苯磺酸盐）。本发明还涉及制备实质上纯的化合物1和化合物1盐的方法。
• [EN] N-(3-FLUOROBENZYL)-2-(5-(4-MORPHOLINOPHENYL)PYRIDIN-2-YL) ACETAMIDE AS PROTEIN|TYROSINE KINASE MODULATORS<br/>[FR] N-(3-FLUOROBENZYL)-2-(5-(4-MORPHOLINOPHENYL)PYRIDIN-2-YL) ACÉTAMIDE UTILISÉ EN TANT QUE MODULATEURS DE LA PROTÉINE TYROSINE KINASE
  申请人：KINEX PHARMACEUTICALS LLC

  公开号：WO2014036426A1

  公开（公告）日：2014-03-06

  The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention also relats to substantially pure compound 1 and substantially pure compound 1 salt (e.g., compound 1 hydrochloride salt and compound 1 benzenesulfonate salt). The invention further relates to methods of preparing substantially pure compound 1 and compound 1 salts.