2-[(dimethylamino)methyl]-N,N'-bis[(Z)-octadec-9-enyl]butanediamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(dimethylamino)methyl]-N,N'-bis[(Z)-octadec-9-enyl]butanediamide
• 化学式: C₄₃H₈₃N₃O₂
• 分子量: 674.1
• InChiKey: XVMKURUSOTYDPV-WRBBJXAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.6
• 重原子数：
  48
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HYALURONIC ACID-NUCLEIC ACID CONJUGATE AND COMPOSITION FOR NUCLEIC ACID DELIVERY CONTAINING THE SAME
  申请人：POSTECH ACADEMY-INDUSTRY FOUNDATION

  公开号：US20140080897A1

  公开（公告）日：2014-03-20

  The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.
• LOW-DENSITY LIPOPROTEIN ANALOGUE NANOPARTICLES, AND COMPOSITION COMPRISING SAME FOR TARGETED DIAGNOSIS AND TREATMENT OF LIVER
  申请人：POSTECH ACADEMY-INDUSTRY FOUNDATION

  公开号：US20150297749A1

  公开（公告）日：2015-10-22

  This disclosure relates to a low density lipoprotein-like cationic solid lipid nanoparticle targeting liver cells including parenchyma cells and non-parenchyma cells, a composition for liver target delivery, a composition for diagnosis and/or treatment of liver disease comprising the same, and a method for liver targeting of an active ingredient.
• [EN] LIPOPROTEIN-MIMICKING SOLID LIPID NANOPARTICLES FOR DRUG DELIVERY AND USES THEREOF<br/>[FR] NANOPARTICULES LIPIDIQUES SOLIDES IMITANT DES LIPOPROTÉINES DESTINÉES À L'ADMINISTRATION DE MÉDICAMENTS ET LEURS UTILISATIONS<br/>[KO] 약물 전달을 위한 지단백 모방 고형 지질 나노입자 및 이의 용도
  申请人：[en]TIONLAB THERAPEUTICS;[ko]주식회사 티온랩테라퓨틱스

  公开号：WO2022255701A1

  公开（公告）日：2022-12-08

  본 발명에 따르면, 알부민이 접합된 콜레스테롤, 융합 유도성 지질, 양이온성 지질, 트리글리세라이드 및 콜레스테릴 에스테르를 구성으로 하는 코어-쉘 구조의 지단백 모방 고형 지질 나노입자를 제조함으로써 생체이용률이 우수하고 약물 봉입 효율이 향상된 약물전달체를 제공할 수 있다.