2-[2-[[Carboxy-(2-hydroxyphenyl)methyl]amino]ethylamino]-2-(2-hydroxyphenyl)acetic acid;2-[2-(1,2-dicarboxyethylamino)ethylamino]butanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2-[[Carboxy-(2-hydroxyphenyl)methyl]amino]ethylamino]-2-(2-hydroxyphenyl)acetic acid;2-[2-(1,2-dicarboxyethylamino)ethylamino]butanedioic acid
• 英文别名: 2-[2-[[carboxy-(2-hydroxyphenyl)methyl]amino]ethylamino]-2-(2-hydroxyphenyl)acetic acid;2-[2-(1,2-dicarboxyethylamino)ethylamino]butanedioic acid
• 化学式: C28H36N4O14
• 分子量: 652.6
• InChiKey: WKBXRYYJLOXGAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.75
• 重原子数：
  46
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  312
• 氢给体数：
  12
• 氢受体数：
  18

文献信息

• Method to concentrate von willebrand factor or complexes thereof
  申请人：CSL LIMITED

  公开号：US10246485B2

  公开（公告）日：2019-04-02

  The present invention relates to a method for concentrating von Willebrand Factor (VWF) from an aqueous solution comprising precipitating the VWF by providing calcium ions and phosphate ions and the subsequent resolubilization of the VWF by means of an aqueous solution comprising a calcium complexing compound.

  本发明涉及一种从水溶液中浓缩 von Willebrand Factor（VWF）的方法，包括通过提供钙离子和磷酸根离子沉淀 VWF，然后通过含有钙络合化合物的水溶液溶解 VWF。
• METHOD OF PURIFYING POLYPEPTIDES
  申请人：CSL Limited

  公开号：EP2513135B1

  公开（公告）日：2020-04-22
• NEW METHOD TO CONCENTRATE VON WILLEBRAND FACTOR OR COMPLEXES THEREOF
  申请人：CSL Limited

  公开号：EP3066119B1

  公开（公告）日：2018-08-01
• METHODS OF PURIFYING POLYPEPTIDES
  申请人：Charlton Adam

  公开号：US20140080200A1

  公开（公告）日：2014-03-20

  The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an ion-exchange matrix relative to the amount of one or more impurities bound to the ion-exchange matrix. This effect is achieved by adding a chemical compound in the process which by also binding to the ion-exchange matrix due to a change that is opposite to the change of the ion-exchange matrix, reduces the binding of impurities more than the binding of the polypeptide of interest.